Activity Dependent Neuroprotector Protein (ADNP) Antibody
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Description
ADNP Antibody is a Rabbit Polyclonal against ADNP.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Activity Dependent Neuroprotector Protein (ADNP) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H2P0 |
| Alias | ADNP, ADNP1, KIAA0784,HVDAS, MRD28 |
| Background | Antibody anti-ADNP |
| Status | RUO |
Descripción
Activity-dependent neuroprotector homeobox protein (ADNP) is a transcription factor and neuroprotective protein essential for brain development, neurogenesis, and chromatin remodeling through interactions with SWI/SNF chromatin-remodeling complexes It regulates gene expression critical for maintaining neuronal survival, synaptic plasticity, and cognitive processes Mutations or deletions in ADNP cause ADNP syndrome (Helsmoortel-Van der Aa syndrome), a neurodevelopmental disorder marked by intellectual disability, autism spectrum disorder traits, motor dysfunction, and developmental delay ADNP is also linked to neurodegenerative diseases, including Alzheimer’s disease, where it modulates tau phosphorylation, amyloid toxicity, and neuronal resilience Dysregulation of ADNP disrupts cell cycle control, proliferation, and apoptosis pathways, leading to impaired neuronal health and cognitive decline ADNP’s broad involvement in transcriptional regulation, synaptic maintenance, and neuroprotection underscores its essential role in brain function, making it a potential therapeutic target for neurodevelopmental and neurodegenerative diseases
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