Activin Receptor Type-1 (ACVR1) Antibody
383.5€ (100 µl)
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935106861
info@markelab.com
name
Activin Receptor Type-1 (ACVR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx224357
tested applications
ELISA, WB, FCM
Description
ACVR1 Antibody is a Mouse Monoclonal against ACVR1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Activin Receptor Type-1 (ACVR1) Immunogen: Purified recombinant fragment of human ACVR1 (AA: 21-120) expressed in E. coli. |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Observed MW | 72 kDa |
| Purification | Purified from ascites by Protein G chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, FCM |
| Buffer | PBS, containing 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P43405 |
| Gene ID | 6850 |
| OMIM | 600085 |
| Alias | ACVRLK2 |
| Background | Antibody anti-ACVR1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
ACVR1, also called ALK2 (Activin Receptor-Like Kinase 2), is a transmembrane serine/threonine kinase receptor. It binds ligands like BMPs (Bone Morphogenetic Proteins), initiating intracellular SMAD signaling. This receptor plays a crucial role in bone development, embryogenesis, and organogenesis. Mutations in ACVR1 are linked to fibrodysplasia ossificans progressiva (FOP), a rare disorder where soft tissues progressively ossify. Structurally, it comprises an extracellular ligand-binding domain, a single transmembrane helix, and an intracellular kinase domain.
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