Activin A Receptor Type 2B (ACVR2B) Antibody (Biotin)
403€ (200 µl)
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935106861
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name
Activin A Receptor Type 2B (ACVR2B) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx273370
tested applications
WB, IHC, IF/ICC
Description
Activin A Receptor Type II B (ACVR2B) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Activin A Receptor Type II B (ACVR2B).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Activin A Receptor Type 2B (ACVR2B) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 200 µl |
| Size 2 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Activin receptor type IIB,ACTR-IIB |
| Background | Antibody anti-ACVR2B |
| Status | RUO |
Descripción
ACVR2B is another type II receptor involved in activin and myostatin signaling pathways. It phosphorylates type I receptors (e.g., ACVR1B) to activate SMAD-dependent signaling cascades. ACVR2B regulates processes like muscle growth, reproductive function, and embryonic development. Inhibition of ACVR2B has been explored as a therapeutic approach for muscle-wasting disorders, such as cachexia and muscular dystrophy. Mutations in ACVR2B can impair ligand-receptor interactions, leading to developmental defects.
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