Activin A Receptor Type 2B (ACVR2B) Antibody

260€ (50 µl)
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935106861
info@markelab.com
name
Activin A Receptor Type 2B (ACVR2B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx214684
tested applications
ELISA, WB, IHC
Description
ACVR2B Antibody is a Rabbit Polyclonal against ACVR2B.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | Activin A Receptor Type 2B (ACVR2B) |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Recommended Dilution | ELISA: 1/1000 - 1/5000, WB: 1/200 - 1/1000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Purification | Antigen Affinity Chromatography. |
Size 1 | 50 µl |
Size 2 | 100 µl |
Form | Liquid |
Tested Applications | ELISA, WB, IHC |
Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
Availability | Shipped within 5-10 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | Q13705 |
Gene ID | 93 |
Alias | Activin receptor type IIB,ACTR-IIB |
Background | Antibody anti-ACVR2B |
Status | RUO |
Descripción
ACVR2B is another type II receptor involved in activin and myostatin signaling pathways. It phosphorylates type I receptors (e.g., ACVR1B) to activate SMAD-dependent signaling cascades. ACVR2B regulates processes like muscle growth, reproductive function, and embryonic development. Inhibition of ACVR2B has been explored as a therapeutic approach for muscle-wasting disorders, such as cachexia and muscular dystrophy. Mutations in ACVR2B can impair ligand-receptor interactions, leading to developmental defects.
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