Activin A Receptor Type 2A (ACVR2A) Antibody
292.5€ (80 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Activin A Receptor Type 2A (ACVR2A) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx028450
Tested Applications
ELISA, WB
Description
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Activin A Receptor Type 2A (ACVR2A) Immunogen: KLH-conjugated synthetic peptide between 22-49 amino acids from the N-terminal region of mouse Acvr2a. |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 57.9 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P27038 |
| Alias | ACVR2,Activin receptor type II,ACTR-IIA |
| Background | Antibody anti-ACVR2A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ACVR2A is a type II receptor that binds activin ligands and subsequently activates type I receptors like ACVR1B. This receptor is integral to TGF-β/activin signaling, mediating cellular processes like growth, differentiation, and apoptosis. ACVR2A is expressed in various tissues, particularly in the reproductive system. Mutations or loss of ACVR2A function are implicated in cancers such as colorectal carcinoma, where its absence disrupts normal cell cycle control and promotes tumor progression.
Productos relacionados
Activin A Receptor Type 2A (ACVR2A) Antibody
ACVR2A Antibody is a Rabbit Polyclonal antibody against ACVR2A. This gene encodes a receptor that mediates the functions…
Ver producto Activin A Receptor Type 2A (ACVR2A) Antibody
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kina…
Ver producto
Activin A Receptor Type 2A (ACVR2A) Antibody
ACVR2A is an activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the tra…
Ver producto