Activin A Receptor Type 2A (ACVR2A) Antibody
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935106861
info@markelab.com
Precio
250€ (80 µl)
Antibody anti-ACVR2A
proveedor
Abbexareference
abx028450Tested Applications
ELISA, WBreactivity
Mousestatus
RUOclonality
PolyclonalDescripción
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
Background
ACVR2A is a type II receptor that binds activin ligands and subsequently activates type I receptors like ACVR1B. This receptor is integral to TGF-β/activin signaling, mediating cellular processes like growth, differentiation, and apoptosis. ACVR2A is expressed in various tissues, particularly in the reproductive system. Mutations or loss of ACVR2A function are implicated in cancers such as colorectal carcinoma, where its absence disrupts normal cell cycle control and promotes tumor progression.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Mouse
immunogen target
Activin A Receptor Type 2A (ACVR2A)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
purification
Purified through a protein A column, followed by peptide affinity purification.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
ACVR2A
dry ice
No
availability
Shipped within 5-10 working days.
alias
ACVR2,Activin receptor type II,ACTR-IIA
uniprot id
note
This product is for research use only.
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Abbexareference
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WB, IHC, IF/ICCreactivity
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proveedor
Abbexareference
abx028450Tested Applications
ELISA, WBreactivity
Mousestatus
RUOclonality
PolyclonalOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kina...
250€ (80 µl)
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