Activin A Receptor Type 1B (ACVR1B) Antibody (Biotin)
169€ (20 µg)
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Name
Activin A Receptor Type 1B (ACVR1B) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx302994
Tested Applications
ELISA
Description
ACVR1B Antibody (Biotin) is a Rabbit Polyclonal against ACVR1B conjugated to Biotin.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Activin A Receptor Type 1B (ACVR1B) Immunogen: Recombinant human Activin receptor type-1B protein (150-300AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P36896 |
| Gene ID | 91 |
| NCBI Accession | NP_004293.1, NM_004302.4 |
| OMIM | 601300 |
| Alias | ACTR-IB,ALK-4,Serine/threonine-protein kinase receptor R2 (SKR2) |
| Background | Antibody anti-ACVR1B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ACVR1B, also known as ALK4, is a type I receptor primarily activated by activins, inhibins, and Nodal ligands. This receptor phosphorylates SMAD2/3 to propagate downstream signaling, which regulates cellular processes such as differentiation, proliferation, and embryonic patterning. ACVR1B is expressed in many tissues, particularly during early development. Mutations in ACVR1B have been associated with tumorigenesis and reproductive disorders due to its role in cell cycle regulation and tissue homeostasis.
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