Activin A Receptor Type 1 (ACVR1) Antibody

Este producto es parte de ACVR - Activin A Receptor Type
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260€ (50 µl)

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935106861
info@markelab.com
name
Activin A Receptor Type 1 (ACVR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx214543
tested applications
ELISA, IHC

Description

ACVR1 Antibody is a Rabbit Polyclonal against ACVR1.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Activin A Receptor Type 1 (ACVR1)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
ELISA: 1/1000 - 1/5000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Antigen Affinity Chromatography.
Size 1
50 µl
Size 2
100 µl
Form
Liquid
Tested Applications
ELISA, IHC
Buffer
PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q04771
Gene ID
90
Alias
ACVRLK2
Background
Antibody anti-ACVR1
Status
RUO

Descripción

ACVR1, also called ALK2 (Activin Receptor-Like Kinase 2), is a transmembrane serine/threonine kinase receptor. It binds ligands like BMPs (Bone Morphogenetic Proteins), initiating intracellular SMAD signaling. This receptor plays a crucial role in bone development, embryogenesis, and organogenesis. Mutations in ACVR1 are linked to fibrodysplasia ossificans progressiva (FOP), a rare disorder where soft tissues progressively ossify. Structurally, it comprises an extracellular ligand-binding domain, a single transmembrane helix, and an intracellular kinase domain.

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