Activated Leukocyte Cell Adhesion Molecule / CD166 (ALCAM) Antibody
169€ (20 µg)
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Name
Activated Leukocyte Cell Adhesion Molecule / CD166 (ALCAM) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx302383
Tested Applications
ELISA, IHC, IF/ICC
Description
ALCAM Antibody is a Rabbit Polyclonal against ALCAM.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Activated Leukocyte Cell Adhesion Molecule / CD166 (ALCAM) Immunogen: Recombinant Human CD166 antigen protein (28-516 AA). |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 5 mg/ml |
| Recommended Dilution | IHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13740 |
| Gene ID | 214 |
| NCBI Accession | NP_001230209.1, NM_001243280.1, NP_001230212.1, NM_001243283.1, NP_001618.2, NM_001627.3 |
| OMIM | 601662 |
| Alias | ALCAM,MEMD,CD166 |
| Background | Antibody anti-ALCAM |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Activated leukocyte cell adhesion molecule (ALCAM), also known as CD166, is a cell surface glycoprotein that belongs to the immunoglobulin superfamily. It plays a significant role in cell-cell adhesion and signaling processes, particularly in the immune system and in various developmental processes. ALCAM is widely expressed in various tissues and cell types, including leukocytes, endothelial cells, neurons, and cancer cells. Its functions include: Cell-Cell Adhesion: ALCAM mediates homophilic (like-to-like) and heterophilic (different molecules) interactions between cells. It facilitates the adhesion of leukocytes to endothelial cells, which is essential for immune cell recruitment to sites of inflammation and in the immune response. Neuronal Development: ALCAM is involved in neuronal migration, axon growth, and guidance during brain development. It helps regulate the formation of neural circuits and synaptic connections. Cancer Progression: ALCAM expression has been implicated in cancer progression and metastasis. It can promote tumor cell migration, invasion, and metastasis by enhancing cell adhesion and facilitating interactions between cancer cells and the surrounding microenvironment.Stem Cell Maintenance: ALCAM is involved in the maintenance and regulation of stem cell populations in various tissues. It plays a role in stem cell adhesion, migration, and differentiation.
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