Activated Leukocyte Cell Adhesion Molecule / CD166 (ALCAM) Antibody
383.5€ (100 µl)
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935106861
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name
Activated Leukocyte Cell Adhesion Molecule / CD166 (ALCAM) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx012112
tested applications
ELISA
Description
This gene encodes ALCAM, also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Activated Leukocyte Cell Adhesion Molecule / CD166 (ALCAM) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13740 |
| Gene ID | 214 |
| OMIM | 601662 |
| Alias | ALCAM,MEMD,CD166 |
| Background | Antibody anti-ALCAM |
| Status | RUO |
| Note | Concentration: Not determined. - |
Descripción
Activated leukocyte cell adhesion molecule (ALCAM), also known as CD166, is a cell surface glycoprotein that belongs to the immunoglobulin superfamily. It plays a significant role in cell-cell adhesion and signaling processes, particularly in the immune system and in various developmental processes. ALCAM is widely expressed in various tissues and cell types, including leukocytes, endothelial cells, neurons, and cancer cells. Its functions include: Cell-Cell Adhesion: ALCAM mediates homophilic (like-to-like) and heterophilic (different molecules) interactions between cells. It facilitates the adhesion of leukocytes to endothelial cells, which is essential for immune cell recruitment to sites of inflammation and in the immune response. Neuronal Development: ALCAM is involved in neuronal migration, axon growth, and guidance during brain development. It helps regulate the formation of neural circuits and synaptic connections. Cancer Progression: ALCAM expression has been implicated in cancer progression and metastasis. It can promote tumor cell migration, invasion, and metastasis by enhancing cell adhesion and facilitating interactions between cancer cells and the surrounding microenvironment.Stem Cell Maintenance: ALCAM is involved in the maintenance and regulation of stem cell populations in various tissues. It plays a role in stem cell adhesion, migration, and differentiation.
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