Actinin Alpha 2 (ACTN2) Antibody

Product specifications

Primary Antibodies

Target: Actinin Alpha 2 (ACTN2)
Immunogen: abx652374 - Recombinant Actinin Alpha 2 (ACTN2)

Rabbit

Human

WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.

100 µl

200 µl

1 ml

Liquid

WB, IHC

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.

Shipped within 5-7 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

ACTN2,CMD1AA,CMH23,MYOCOZ,MPD6

Antibody anti-ACTN2

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

ACTN2 encodes alpha-actinin-2, a muscle-specific isoform of the actinin family, expressed predominantly in cardiac and skeletal muscle tissues. It functions as a structural component of the sarcomere, anchoring actin filaments to the Z-discs and contributing to the maintenance of sarcomere integrity during muscle contraction. ACTN2 also plays a role in signal transduction by interacting with a variety of signaling and cytoskeletal proteins, modulating muscle development and repair. Mutations in ACTN2 are associated with cardiomyopathies, including hypertrophic and dilated cardiomyopathy, where impaired sarcomeric organization leads to reduced cardiac function. Its critical role in sarcomere structure and interaction with signaling pathways highlights its importance in maintaining muscle function and responding to mechanical stress.

Related Products

Human Actinin Alpha 2 (ACTN2) Protein

Human Actinin Alpha 2 (ACTN2) Protein is a recombinant Human protein expressed in E. coli.

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