Actinin alpha-2 / 3 Cell ELISA Kit
513.5€ (96 tests)
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Name
Actinin alpha-2 / 3 Cell ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx595743
Tested Applications
ELISA
Description
Actinin alpha-2/3 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Immunogen Target | Actinin alpha-2/3 |
| Reactivity | Human, Mouse, Rat |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P35609, Q08043 |
| Gene ID | 88, 89 |
| OMIM | 102573 |
| Alias | ACTN2,CMD1AA,CMH23,MYOCOZ,MPD6 |
| Background | Elisa Kits for: ACTN2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Background
ACTN2 encodes alpha-actinin-2, a muscle-specific isoform of the actinin family, expressed predominantly in cardiac and skeletal muscle tissues. It functions as a structural component of the sarcomere, anchoring actin filaments to the Z-discs and contributing to the maintenance of sarcomere integrity during muscle contraction. ACTN2 also plays a role in signal transduction by interacting with a variety of signaling and cytoskeletal proteins, modulating muscle development and repair. Mutations in ACTN2 are associated with cardiomyopathies, including hypertrophic and dilated cardiomyopathy, where impaired sarcomeric organization leads to reduced cardiac function. Its critical role in sarcomere structure and interaction with signaling pathways highlights its importance in maintaining muscle function and responding to mechanical stress.
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