Actin Like 7A (ACTL7A) Antibody

Background

ACTL7A is a testis-specific actin-like protein predominantly expressed during spermatogenesis. It shares structural homology with canonical actins, including an ATP/ADP-binding site critical for nucleotide interactions. However, ACTL7A does not polymerize into filaments and instead performs unique roles in germ cell cytoskeletal dynamics. It is involved in chromatin remodeling during spermatid maturation, assisting in nuclear shaping and acrosome biogenesis. ACTL7A expression is tightly regulated, and disruptions in its function can lead to male infertility due to defects in sperm morphology and motility.