Actin-Binding LIM Protein 2 (ABLIM2) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Actin-Binding LIM Protein 2 (ABLIM2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230055
tested applications
ELISA, WB, IHC
Description
ABLIM2 Antibody is a Rabbit Polyclonal against ABLIM2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Actin-Binding LIM Protein 2 (ABLIM2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/5000, IHC: 1/20 - 1/200, IP: 1/500 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6H8Q1 |
| Gene ID | 84448 |
| OMIM | 612544 |
| Alias | ABLIM2 |
| Background | Antibody anti-ABLIM2 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
ABLIM2 is a member of the actin-binding LIM protein family, involved in actin filament organization and signal transduction. It contains LIM domains that mediate interactions with various cytoskeletal and signaling proteins, and its actin-binding domains allow it to associate with the actin cytoskeleton. ABLIM2 is highly expressed in sensory neurons and the retina, where it plays a role in maintaining cytoskeletal integrity and supporting neural signaling pathways. This protein is also implicated in processes such as axonal growth and guidance, as well as in mechanotransduction, the conversion of mechanical stimuli into biochemical signals. Dysregulation of ABLIM2 may contribute to sensory neuron dysfunction and retinal degeneration, underscoring its role in neural development and maintenance. Its interaction with cytoskeletal proteins highlights its significance in cellular architecture and mechanical signal processing.
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