Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member B (ANP32B) Antibody
52€ (10 µg)
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Name
Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member B (ANP32B) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx249448
Tested Applications
WB
Description
ANP32B Antibody is a Rabbit Polyclonal against ANP32B.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member B (ANP32B) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92688 |
| Gene ID | 10541 |
| Alias | ANP32B,APRIL,PHAPI2 |
| Background | Antibody anti-ANP32B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ANP32B is a nuclear phosphoprotein that shares structural and functional similarities with ANP32A, particularly in chromatin regulation and RNA processing. ANP32B functions as a regulator of apoptosis, cell proliferation, and gene transcription, making it critical for cellular homeostasis and growth control. It is essential for embryonic development, with knockout studies indicating its requirement for cell survival and proper organogenesis. ANP32B also modulates the activity of HDAC complexes, contributing to histone deacetylation and transcriptional repression. Dysregulation of ANP32B has been linked to cancer progression and metastasis, where it promotes cell proliferation and resistance to apoptosis. Its involvement in multiple pathways underscores its importance as a potential therapeutic target in oncology.
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