Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member B (ANP32B) Antibody
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Description
ANP32B Antibody is a Mouse Monoclonal against ANP32B.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member B (ANP32B) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2b |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92688 |
| Gene ID | 10541 |
| Alias | ANP32B,APRIL,PHAPI2 |
| Background | Antibody anti-ANP32B |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
ANP32B is a nuclear phosphoprotein that shares structural and functional similarities with ANP32A, particularly in chromatin regulation and RNA processing. ANP32B functions as a regulator of apoptosis, cell proliferation, and gene transcription, making it critical for cellular homeostasis and growth control. It is essential for embryonic development, with knockout studies indicating its requirement for cell survival and proper organogenesis. ANP32B also modulates the activity of HDAC complexes, contributing to histone deacetylation and transcriptional repression. Dysregulation of ANP32B has been linked to cancer progression and metastasis, where it promotes cell proliferation and resistance to apoptosis. Its involvement in multiple pathways underscores its importance as a potential therapeutic target in oncology.
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Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A(PP2A) inhibitor activity(By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.
Ver ProductoANP32B antibody
Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A(PP2A) inhibitor activity(By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.
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