1-Acylglycerol-3-Phosphate O-Acyltransferase ABHD5 (ABHD5) Antibody (HRP)
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Description
ABHD5 Antibody (HRP) is a Rabbit Polyclonal against ABHD5 conjugated to HRP.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | 1-Acylglycerol-3-Phosphate O-Acyltransferase ABHD5 (ABHD5) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WTS1 |
| Gene ID | 51099 |
| OMIM | 275630 |
| Alias | CGI58,IECN2,NCIE2 |
| Background | Antibody anti-ABHD5 |
| Status | RUO |
Descripción
ABHD5, also known as CGI-58, is a critical coactivator of adipose triglyceride lipase (ATGL), a key enzyme in lipolysis. It promotes the hydrolysis of triglycerides into glycerol and free fatty acids, thereby regulating lipid storage and energy metabolism. ABHD5 is highly expressed in adipose tissue, liver, and muscles, where it plays an essential role in lipid mobilization and energy balance. Mutations in the ABHD5 gene are associated with Chanarin-Dorfman syndrome, a rare lipid storage disorder characterized by excessive lipid accumulation in various tissues. Beyond lipolysis, ABHD5 influences lipid signaling pathways and cellular lipid composition, affecting processes such as inflammation and metabolic homeostasis. Dysregulation of ABHD5 activity can contribute to obesity, insulin resistance, and other metabolic syndromes, highlighting its critical role in energy regulation and lipid metabolism.
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