Abhydrolase Domain Containing 12 (ABHD12) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Abhydrolase Domain Containing 12 (ABHD12) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx034149
tested applications
ELISA, WB, IHC, FCM
Description
ABHD12 has 2-arachidonoylglycerol hydrolase activity (By similarity). It may be a regulator of endocannabinoid signaling pathways (By similarity).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Abhydrolase Domain Containing 12 (ABHD12) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8N2K0 |
| Alias | ABHD12A,BEM46L2,C20orf22,PHARC |
| Background | Antibody anti-ABHD12 |
| Status | RUO |
Descripción
ABHD12 (Abhydrolase Domain Containing 12) is a membrane-bound serine hydrolase primarily involved in lipid metabolism and neuroinflammatory regulation. It plays a critical role in degrading lysophosphatidylserine (lyso-PS), a bioactive lipid mediator involved in immune signaling. ABHD12 is highly expressed in the brain and other tissues, where it regulates lipid signaling pathways crucial for neural function and homeostasis. Mutations in the ABHD12 gene are associated with PHARC syndrome (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataracts), a neurodegenerative disorder. This enzyme’s activity is essential for maintaining balanced lipid signaling and protecting against neuroinflammation and neurodegeneration.
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