A-Kinase Anchoring Protein 13 (AKAP13) Antibody
221€ (50 µg)
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935106861
info@markelab.com
name
A-Kinase Anchoring Protein 13 (AKAP13) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx324510
tested applications
ELISA, WB, IHC
Description
AKAP13 Antibody is a Rabbit Polyclonal against AKAP13.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | A-Kinase Anchoring Protein 13 (AKAP13) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q12802 |
| Gene ID | 11214 |
| Alias | AKAP-13,AKAP-Lbc,ARHGEF13 |
| Background | Antibody anti-AKAP13 |
| Status | RUO |
Descripción
AKAP13, also known as BRX (BRE-1-related exchange factor), is a scaffold protein that not only binds PKA but also acts as a guanine nucleotide exchange factor (GEF) for Rho family GTPases, such as RhoA. AKAP13 plays a critical role in the regulation of cytoskeletal dynamics, cell migration, and proliferation through crosstalk between PKA and Rho signaling pathways. Its Rho-GEF activity regulates actin cytoskeleton organization, influencing processes like adhesion, morphogenesis, and stress fiber formation. AKAP13 is a key regulator of cardiac hypertrophy and heart development, where it mediates PKA and RhoA signaling in cardiomyocytes under mechanical stress. Dysregulation of AKAP13 has been implicated in cancer progression, as it promotes tumor cell motility and invasion through enhanced cytoskeletal reorganization and focal adhesion dynamics. AKAP13 also interacts with steroid hormone receptors, such as estrogen and glucocorticoid receptors, linking it to transcriptional regulation in hormonal signaling pathways. Studies show that AKAP13 mutations are associated with developmental disorders, cardiac anomalies, and hormone-driven cancers.
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