A-Kinase Anchor Protein 7 Isoform Gamma (AKAP7) Antibody
377€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
A-Kinase Anchor Protein 7 Isoform Gamma (AKAP7) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx230257
Tested Applications
ELISA, WB, IHC, IF/ICC, IP
Description
AKAP7 Antibody is a Rabbit Polyclonal against AKAP7.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: A-Kinase Anchor Protein 7 Isoform Gamma (AKAP7) Immunogen: A kinase(PRKA) anchor protein 7 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/200 - 1/2000, IHC: 1/20 - 1/200, IF/ICC: 1/10 - 1/100, IP: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 9 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, IP |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9P0M2 |
| Alias | AKAP7, AKAP18 |
| Background | Antibody anti-AKAP7 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AKAP7, also referred to as AKAP15/18, is a small, membrane-associated scaffold protein that localizes PKA and other signaling molecules to the plasma membrane and sarcoplasmic reticulum (SR) in excitable cells, such as neurons and cardiac myocytes. AKAP7 regulates PKA-dependent phosphorylation of L-type calcium channels, ensuring proper calcium influx during action potentials, which is critical for cardiac and neuronal excitability. It also interacts with phospholamban to modulate SR calcium uptake through SERCA2 pumps, impacting cardiac muscle relaxation. AKAP7 isoforms have diverse roles, with AKAP18γ and AKAP18δ being involved in anchoring signaling components to SR and plasma membranes. Dysregulation of AKAP7 impairs calcium handling, leading to arrhythmias, cardiac dysfunction, and impaired synaptic plasticity. AKAP7 has also been implicated in insulin secretion in pancreatic beta cells, where it organizes signaling components involved in glucose-stimulated calcium responses.
Productos relacionados
A-Kinase Anchor Protein 7 Isoform Gamma (AKAP7) Antibody
Rabbit Polyclonal against the AKAP7 protein.…
Ver producto
Human A-Kinase Anchor Protein 7 Isoform Gamma (AKAP7) Protein
Human A Kinase Anchor Protein 7 Protein is a recombinant protein kinase.…
Ver producto
A-Kinase Anchor Protein 7 Isoform Gamma (AKAP7) Antibody
AKAP7 Antibody is a Rabbit Polyclonal against AKAP7.…
Ver producto