A-Kinase Anchor Protein 10, Mitochondrial (AKAP10) Antibody
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Description
AKAP10 Antibody is a Goat Polyclonal antibody against AKAP10.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | A-Kinase Anchor Protein 10, Mitochondrial (AKAP10) |
| Host | Goat |
| Reactivity | Rat |
| Recommended Dilution | P-ELISA: 1/64000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 11216, 56697, 360540 |
| NCBI Accession | NP_009133.2 |
| Alias | AKAP-10,D-AKAP-2,D-AKAP2,PRKA10 |
| Background | Antibody anti-AKAP10 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
AKAP10, also known as dual-specific AKAP2 (D-AKAP2), is a dual-targeting scaffold protein that binds to PKA and other signaling proteins at cellular membranes, including mitochondria and plasma membranes. AKAP10 regulates PKA signaling in pathways related to cardiac function, mitochondrial biogenesis, and cellular energy metabolism. Polymorphisms in AKAP10, such as the I646V variant, are associated with altered heart rate, reduced heart rate variability, and an increased risk of arrhythmias, highlighting its importance in cardiovascular homeostasis. AKAP10 also interacts with mitochondrial proteins to regulate energy production, enhancing ATP synthesis and oxidative phosphorylation. AKAP10 has been implicated in apoptosis, where its role in PKA-dependent signaling ensures mitochondrial integrity during cellular stress. Additionally, AKAP10 participates in cell migration and polarity by organizing signaling complexes near the plasma membrane, influencing cytoskeletal reorganization and adhesion dynamics in cancer metastasis.
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