A-Kinase Anchor Protein 10, Mitochondrial (AKAP10) Antibody
169€ (20 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
A-Kinase Anchor Protein 10, Mitochondrial (AKAP10) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx320511
Tested Applications
ELISA, IHC
Description
AKAP10 Antibody is a Rabbit Polyclonal against AKAP10.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: A-Kinase Anchor Protein 10, Mitochondrial (AKAP10) Immunogen: Recombinant human A-kinase anchor protein 10, mitochondrial protein (413-662AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43572 |
| Gene ID | 11216 |
| OMIM | 115080 |
| Alias | AKAP-10,D-AKAP-2,D-AKAP2,PRKA10 |
| Background | Antibody anti-AKAP10 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AKAP10, also known as dual-specific AKAP2 (D-AKAP2), is a dual-targeting scaffold protein that binds to PKA and other signaling proteins at cellular membranes, including mitochondria and plasma membranes. AKAP10 regulates PKA signaling in pathways related to cardiac function, mitochondrial biogenesis, and cellular energy metabolism. Polymorphisms in AKAP10, such as the I646V variant, are associated with altered heart rate, reduced heart rate variability, and an increased risk of arrhythmias, highlighting its importance in cardiovascular homeostasis. AKAP10 also interacts with mitochondrial proteins to regulate energy production, enhancing ATP synthesis and oxidative phosphorylation. AKAP10 has been implicated in apoptosis, where its role in PKA-dependent signaling ensures mitochondrial integrity during cellular stress. Additionally, AKAP10 participates in cell migration and polarity by organizing signaling complexes near the plasma membrane, influencing cytoskeletal reorganization and adhesion dynamics in cancer metastasis.
Productos relacionados
A-Kinase Anchor Protein 10, Mitochondrial (AKAP10) Antibody
Rabbit polyclonal antibody against AKAP10 protein. Immunogen region is N-terminal.…
Ver producto A-Kinase Anchor Protein 10, Mitochondrial (AKAP10) Antibody
Rabbit Polyclonal against the AKAP10 protein.…
Ver producto
A-Kinase Anchor Protein 10, Mitochondrial (AKAP10) Antibody
AKAP10 Antibody is a Rabbit Polyclonal against AKAP10.…
Ver producto