A Disintegrin And Metalloprotease 28 (ADAM28) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
A Disintegrin And Metalloprotease 28 (ADAM28) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx210613
tested applications
ELISA, IHC
Description
ADAM28 Antibody is a Rabbit Polyclonal against ADAM28.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | A Disintegrin And Metalloprotease 28 (ADAM28) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UKQ2 |
| Gene ID | 10863 |
| Alias | EMDCII, MDC-Lm, MDC-Ls,Cysteine-Rich Protein II,MDCL,adam-28 |
| Background | Antibody anti-ADAM28 |
| Status | RUO |
Descripción
ADAM28 (A Disintegrin And Metalloproteinase domain-containing protein 28) is a member of the ADAM (a disintegrin and metalloproteinase) family of proteins. Like other members of this family, ADAM28 contains several distinct domains, including a metalloproteinase domain, a disintegrin domain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and a cytoplasmic tail. These domains confer diverse functions to ADAM28, including proteolytic activity, cell adhesion, cell signaling, and regulation of protein-protein interactions.ADAM28 is primarily expressed in the testis, but it is also found in other tissues such as the spleen, lymph nodes, and thymus. In addition to its presence in normal tissues, ADAM28 expression has been detected in certain pathological conditions, including various cancers such as breast cancer, ovarian cancer, and prostate cancer. Its expression in these cancers suggests potential roles in tumor progression, invasion, and metastasis.ADAM28 has been implicated in immune responses and inflammatory processes. It is expressed in immune cells such as macrophages and dendritic cells, where it may participate in cell-cell interactions, cytokine signaling, and immune cell activation.
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