5-Hydroxytryptamine Receptor 7 / 5-HT7 (HTR7) Antibody
702€ (50 µg)
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Name
5-Hydroxytryptamine Receptor 7 / 5-HT7 (HTR7) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx411941
Tested Applications
IHC
Description
5-Hydroxytryptamine Receptor 7 (HTR7) Antibody is a Rabbit Polyclonal antibody against 5-HT7 RECEPTOR.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: 5-Hydroxytryptamine Receptor 7 / 5-HT7 (HTR7) |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1.0 mg/ml |
| Recommended Dilution | Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified |
| Size 1 | 50 µg |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | PBS. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P34969 |
| Alias | HTR7,5-HT7,5-HT7 receptor |
| Background | Antibody anti-HTR7 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
HTR7 is a serotonin receptor belonging to the G protein-coupled receptor (GPCR) family that activates adenylate cyclase upon binding to serotonin (5-HT), leading to increased cAMP production. It is widely expressed in the central nervous system, including the thalamus, hypothalamus, hippocampus, and the spinal cord, where it regulates critical functions such as mood, circadian rhythms, sleep, and thermoregulation. HTR7 is also expressed in peripheral tissues, including the gastrointestinal tract and vascular smooth muscles, where it modulates gut motility and vascular tone. Dysregulation of HTR7 signaling has been linked to mood disorders such as depression and bipolar disorder, as well as to sleep disturbances and migraine pathophysiology. Additionally, HTR7 has been implicated in inflammatory diseases and neurodevelopmental disorders due to its influence on neuronal connectivity and immune responses. Pharmacologically, selective HTR7 antagonists have demonstrated antidepressant and anxiolytic effects, making the receptor an attractive target for mood disorder therapies. Furthermore, HTR7 has potential roles in the management of pain and migraine, given its regulatory function in the pain processing pathways. Its broad physiological roles underscore its importance in maintaining neurological homeostasis and suggest therapeutic opportunities in both CNS disorders and systemic diseases.
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