5-Hydroxytryptamine Receptor 4 (HTR4) Antibody (Biotin)

Este producto es parte de HTR - 5-Hydroxytryptamine receptors
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169€ (20 µg)

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935106861
info@markelab.com
name
5-Hydroxytryptamine Receptor 4 (HTR4) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx334511
tested applications
ELISA

Description

HTR4 Antibody (Biotin) is a Rabbit Polyclonal against HTR4.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
5-Hydroxytryptamine Receptor 4 (HTR4)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Biotin
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q13639
Gene ID
3360
Alias
HTR4,5-HT4, 5-HT4R,5-HT4 receptor
Background
Antibody anti-HTR4
Status
RUO

Descripción

HTR4 is a G protein-coupled receptor (GPCR) that mediates the effects of serotonin (5-HT) through adenylate cyclase activation, increasing intracellular levels of cyclic AMP (cAMP). This receptor is widely expressed in the central nervous system, gastrointestinal tract, cardiovascular system, and urinary tissues, where it regulates processes such as memory, learning, mood modulation, peristalsis, and heart function. In the brain, HTR4 is particularly abundant in the hippocampus, cortex, and basal ganglia, contributing to cognitive function and mood stabilization. Activation of HTR4 receptors has anxiolytic and antidepressant effects, making it a promising target for mood disorders, including depression and anxiety. In the gastrointestinal system, HTR4 enhances motility by stimulating enteric neurons, leading to its therapeutic use in treating gastroesophageal reflux disease (GERD) and constipation. Research suggests that HTR4 plays a role in neurodegenerative diseases such as Alzheimer's disease due to its influence on acetylcholine release, promoting synaptic plasticity. Its pharmacological significance extends to therapies aimed at enhancing cognitive function, improving GI motility, and alleviating mood disorders.

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