5-Hydroxytryptamine Receptor 3A (HTR3A) Antibody (Biotin)
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Description
HTR3A Antibody (Biotin) is a Rabbit Polyclonal against HTR3A conjugated to Biotin.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | 5-Hydroxytryptamine Receptor 3A (HTR3A) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P46098 |
| Gene ID | 3359 |
| NCBI Accession | NP_000860.2, NM_000869.5 |
| OMIM | 182139 |
| Alias | HTR3A,HTR3, 5HT3R, 5-HT-3, 5-HT3A, 5-HT3R,5-HT3A receptor |
| Background | Antibody anti-HTR3A |
| Status | RUO |
Descripción
HTR3A is a subunit of the 5-HT3 receptor, a ligand-gated ion channel receptor that differs from the G protein-coupled serotonin receptors (5-HT1, 2, etc.). Found primarily in the central nervous system (CNS) and peripheral nervous system (PNS), HTR3A mediates fast excitatory neurotransmission in response to serotonin (5-HT). The receptor's activation allows for the influx of sodium (Na+) and calcium (Ca2+) ions across the neuronal membrane, leading to neuronal depolarization. HTR3A is crucial in regulating physiological processes such as nausea and vomiting, gastrointestinal motility, anxiety, and pain perception. It is highly expressed in the area postrema, a brain region involved in emetic responses. Consequently, 5-HT3 receptor antagonists like ondansetron are used clinically to prevent chemotherapy-induced nausea and vomiting (CINV). In the enteric nervous system, HTR3A modulates peristalsis and visceral pain, making it relevant for irritable bowel syndrome (IBS) treatment. Dysregulation of HTR3A function has also been implicated in neuropsychiatric disorders, including anxiety, depression, and schizophrenia. Genetic polymorphisms of HTR3A have been associated with heightened anxiety sensitivity and increased risk of mood disorders, indicating its therapeutic importance in both gastrointestinal and neurological contexts.
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The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.
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