5-Hydroxytryptamine Receptor 3A (HTR3A) Antibody
169€ (20 µg)
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Name
5-Hydroxytryptamine Receptor 3A (HTR3A) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx318740
Tested Applications
ELISA, WB, IF/ICC
Description
HTR3A Antibody is a Rabbit Polyclonal against HTR3A.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: 5-Hydroxytryptamine Receptor 3A (HTR3A) Immunogen: Recombinant Human 5-hydroxytryptamine receptor 3A protein (322-455AA). |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/5000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P46098 |
| Gene ID | 3359 |
| NCBI Accession | NP_000860.2, NM_000869.5 |
| OMIM | 182139 |
| Alias | HTR3A,HTR3, 5HT3R, 5-HT-3, 5-HT3A, 5-HT3R,5-HT3A receptor |
| Background | Antibody anti-HTR3A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
HTR3A is a subunit of the 5-HT3 receptor, a ligand-gated ion channel receptor that differs from the G protein-coupled serotonin receptors (5-HT1, 2, etc.). Found primarily in the central nervous system (CNS) and peripheral nervous system (PNS), HTR3A mediates fast excitatory neurotransmission in response to serotonin (5-HT). The receptor's activation allows for the influx of sodium (Na+) and calcium (Ca2+) ions across the neuronal membrane, leading to neuronal depolarization. HTR3A is crucial in regulating physiological processes such as nausea and vomiting, gastrointestinal motility, anxiety, and pain perception. It is highly expressed in the area postrema, a brain region involved in emetic responses. Consequently, 5-HT3 receptor antagonists like ondansetron are used clinically to prevent chemotherapy-induced nausea and vomiting (CINV). In the enteric nervous system, HTR3A modulates peristalsis and visceral pain, making it relevant for irritable bowel syndrome (IBS) treatment. Dysregulation of HTR3A function has also been implicated in neuropsychiatric disorders, including anxiety, depression, and schizophrenia. Genetic polymorphisms of HTR3A have been associated with heightened anxiety sensitivity and increased risk of mood disorders, indicating its therapeutic importance in both gastrointestinal and neurological contexts.
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