5-Hydroxytryptamine Receptor 2C (HTR2C) Antibody

Documentos del producto

Especificaciones del producto

Primary Antibodies

Target: 5-Hydroxytryptamine Receptor 2C (HTR2C)
Immunogen: A synthesized peptide derived from human 5HT2C Receptor

Rabbit

Human

WB: 1/500 - 1/5000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.

Monoclonal

Unconjugated

IgG

Recombinant

Purified by affinity chromatography.

50 µl

100 µl

Liquid

ELISA, WB, IHC

PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

P28335

3358, 15560

HTR2C,HTR1C, 5-HT1C, 5-HT2C, 5HTR2C, 5-HTR2C,5-HT2C receptor

Antibody anti-HTR2C

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Background

HTR2C is a serotonin receptor subtype located primarily in the central nervous system (CNS), particularly in the hypothalamus, choroid plexus, and limbic regions, where it regulates mood, appetite, and metabolic processes. As a G protein-coupled receptor (GPCR), HTR2C exerts its effects by activating intracellular signaling cascades, including the phospholipase C pathway. HTR2C plays a critical role in energy homeostasis and appetite suppression, contributing to its regulation of body weight. Agonism of HTR2C receptors promotes the release of pro-opiomelanocortin (POMC) in hypothalamic neurons, leading to reduced food intake and increased energy expenditure. Drugs such as lorcaserin, a selective HTR2C agonist, have been used to treat obesity by reducing appetite. HTR2C is also implicated in neuropsychiatric disorders, including depression, anxiety, schizophrenia, and substance abuse. Genetic polymorphisms and dysfunction in HTR2C signaling have been linked to metabolic syndrome, antipsychotic-induced weight gain, and insulin resistance, particularly in patients undergoing psychiatric treatments. Furthermore, HTR2C modulates dopaminergic and noradrenergic systems, which play roles in motivation, reward, and mood regulation. Its influence on behaviors such as impulsivity, cognition, and stress responses makes HTR2C a significant target for obesity management, mood stabilization, and substance use disorders. Understanding the therapeutic modulation of HTR2C holds promise for treating both metabolic and psychiatric conditions.