5-Hydroxytryptamine Receptor 2A (HTR2A) Antibody (Biotin)

Este producto es parte de HTR - 5-Hydroxytryptamine receptors
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169€ (20 µg)

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935106861
info@markelab.com
name
5-Hydroxytryptamine Receptor 2A (HTR2A) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx304189
tested applications
ELISA

Description

HTR2A Antibody (Biotin) is a Rabbit Polyclonal against HTR2A conjugated to Biotin.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
5-Hydroxytryptamine Receptor 2A (HTR2A)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Biotin
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P28223
Gene ID
3356
NCBI Accession
NP_000612.1, NM_000621.4
OMIM
182135
Alias
HTR2A,HTR2, 5-HT2A,5-HT2A receptor
Background
Antibody anti-HTR2A
Status
RUO

Descripción

HTR2A is a G protein-coupled receptor (GPCR) that mediates the actions of serotonin (5-HT), a neurotransmitter crucial for mood regulation, perception, and cognition. It is widely expressed in the central nervous system (CNS), particularly in the prefrontal cortex, hippocampus, and amygdala, regions involved in executive function, emotion, and learning. HTR2A is highly implicated in neuropsychiatric conditions, including schizophrenia, depression, anxiety, and mood disorders. Its activation influences intracellular calcium signaling and downstream pathways such as the phospholipase C cascade. HTR2A also interacts with various neurotransmitter systems, including dopamine, glutamate, and norepinephrine, which are critical for regulating mood and behavior. Importantly, many antipsychotic drugs, such as risperidone and clozapine, function as antagonists of HTR2A, improving symptoms of psychosis and mood stabilization. It is also the principal target for psychedelic compounds, like LSD and psilocybin, which bind to HTR2A and induce altered perceptions and consciousness. Genetic polymorphisms in the HTR2A gene have been associated with an increased risk of major depressive disorder and resistance to antidepressant therapy. Understanding HTR2A's role in serotonin signaling, mood regulation, and cognitive processes makes it a crucial target for pharmacological intervention in a range of psychiatric and neurodevelopmental disorders.

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