4-Hydroxy-2-hexenal Antibody (ATTO390)
741€ (100 µg)
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Name
4-Hydroxy-2-hexenal Antibody (ATTO390)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx440264
Tested Applications
ELISA, WB, IF/ICC, FCM, FACS
Description
4-Hydroxy-2-hexenal Antibody is a Mouse Monoclonal conjugated to ATTO 390 against 4-Hydroxy-2-hexenal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: 4-Hydroxy-2-hexenal Immunogen: Synthetic 4-Hydroxy-2-hexenal modified Keyhole Limpet Hemocyanin (KLH).. |
| Host | Mouse |
| Reactivity | General |
| Detection Method | Laser Line: 390 Excitation/Emission: 390/476 |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | ELISA: 1/1000, WB: 1/1000, IF/ICC: 1/50, FCM: 1/50, FACS: 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | ATTO390 |
| Isotype | IgG2b |
| Purification | Purified by Protein G. |
| Size 1 | 100 µg |
| Tested Applications | ELISA, WB, IF/ICC, FCM, FACS |
| Buffer | PBS, pH 7.4, 50% glycerol, 0.09% sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at 4°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | TRANS-4-HYDROXY-2-HEXENAL |
| Background | Antibody anti-4-HHE |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
4-Hydroxy-2-hexenal (4-HHE) is a highly reactive lipid peroxidation product derived from the oxidation of omega-3 polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). It is a reactive aldehyde that can modify proteins, nucleic acids, and lipids through covalent binding, leading to cellular damage or signaling modulation. 4-HHE plays a dual role in biological systems: at low concentrations, it acts as a signaling molecule regulating cellular responses like antioxidant defense and apoptosis, while at high levels, it induces cytotoxicity and contributes to oxidative stress. Elevated 4-HHE levels are associated with pathological conditions, including neurodegenerative diseases, cardiovascular disorders, and inflammation. Its formation is a marker of oxidative stress and can disrupt cellular homeostasis by altering protein function and membrane integrity. Studies continue to explore its role in modulating redox signaling and as a potential biomarker for lipid peroxidation-related damage.
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