Family main features
Triggering receptor expressed on myeloid cells 1 (TREM1) is an immunoglobulin (Ig) superfamily receptor predominantly expressed on myeloid cells, such as neutrophils, monocytes, macrophages, and dendritic cells. TREM1 is recognized for its role in amplifying inflammatory responses during infections and other inflammatory conditions, and it plays a significant part in innate immune regulation. TREM1 is a potent activator of inflammatory responses and is known to amplify signaling from pattern recognition receptors (PRRs) such as toll-like receptors (TLRs). Through these amplifying actions, TREM1 enhances the immune system’s ability to clear pathogens but also has the potential to contribute to pathological inflammation.
TREM1 activation is linked with inflammatory cytokine production, chemotaxis, and cellular responses involved in pathogen clearance. In addition to pathogen responses, TREM1 is implicated in sterile inflammation, where it is upregulated during non-infectious inflammation, such as that observed in autoimmune diseases, cancer, and tissue damage. Its role in amplifying inflammatory cascades makes TREM1 a focal point for research into immune regulation and as a therapeutic target for controlling inflammation-related diseases.
TREM1 is a single-pass type I transmembrane receptor consisting of approximately 230 amino acids. Its structure is characterized by three primary domains:
Extracellular Domain:
Transmembrane Domain:
Cytoplasmic (Intracellular) Domain:
TREM1 belongs to the TREM family within the immunoglobulin superfamily. The TREM family includes TREM1, TREM2, and other related receptors that regulate immune responses by activating or inhibiting signaling pathways in myeloid cells. While TREM1 is primarily involved in amplifying inflammation, TREM2 is associated with immune regulation and anti-inflammatory signaling, particularly in microglial cells within the central nervous system.
TREM1 does not have known isoforms or subtypes in humans, although its expression and activity may be regulated differently depending on cell type and tissue context. TREM1's structure and function are highly conserved among mammals, highlighting its essential role in innate immunity across species.
TREM1 is a major amplifier of inflammatory responses in myeloid cells. Its functions and biological significance can be summarized as follows:
Amplification of Inflammatory Responses:
Role in Innate Immune Cell Activation:
Modulation of Sterile Inflammation:
Synergy with Other Immune Receptors:
Sepsis and Severe Infections:
Chronic Inflammatory Diseases:
Cancer:
Cardiovascular Diseases:
TREM1 is a member of the immunoglobulin superfamily that plays a critical role in amplifying inflammatory responses in myeloid cells. It has a distinct protein structure that includes an extracellular Ig-like domain, a transmembrane region that interacts with the DAP12 adaptor, and a short intracellular tail that relies on DAP12 for signaling. This interaction with DAP12 activates signaling pathways that lead to the production of inflammatory cytokines and chemokines, amplifying responses to pathogens and contributing to the recruitment and activation of immune cells.
Functionally, TREM1 is central to the regulation of inflammation, particularly during infections and sterile inflammatory conditions. Its role in amplifying responses places it at the core of several inflammatory diseases, where excessive TREM1 activity is associated with adverse outcomes. In sepsis, chronic inflammatory diseases, cancer, and cardiovascular diseases, TREM1’s amplification of immune responses can lead to tissue damage, suggesting its potential as a therapeutic target. Consequently, modulation of TREM1 activity is being investigated to manage inflammation-related diseases, aiming to balance effective immune responses with the prevention of pathological inflammation.
triggering receptor expressed on myeloid cells 1 (TREM1)
Triggering receptor expressed on monocytes 1,CD354,TREM-1
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | TREM1 | abx575539 | Cow Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) ELISA Kit | Cow | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q6QUN5 | RUO | ||
Abbexa | TREM1 | abx197844 | Human Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | TREM1 | abx153386 | Human Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 6.5 pg/ml | 500 | 96 tests | RUO | |
Abbexa | TREM1 | abx253495 | Human Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 62.5 pg/ml - 4000 pg/ml | 37.5 pg/ml | 493.75 | 96 tests | Q9NP99 | RUO |
Abbexa | TREM1 | abx190092 | Human Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) CLIA Kit | Human | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 2.74 pg/ml - 2000 pg/ml | < 1.12 pg/ml | 812.5 | 96 tests | RUO | |
FineTest | TREM1 | EM0199 | Mouse TREM-1(Triggering Receptor Expresses on Myeloid Cells-1) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 7.813-500pg/ml | 96T | Q9JKE2 | RUO | ||
Abbexa | TREM1 | abx197845 | Mouse Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) CLIA Kit | Mouse | Serum, plasma and other biological fluids. | Sandwich | 3.13 pg/ml - 200 pg/ml | 1.88 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | TREM1 | abx254574 | Mouse Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 7.81 pg/ml - 500 pg/ml | 4.69 pg/ml | 525 | 96 tests | Q9JKE2 | RUO |
Abbexa | TREM1 | abx491223 | Mouse Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) CLIA Kit | Mouse | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 15.62 pg/ml - 1000 pg/ml | < 6.7 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | TREM1 | abx154805 | Mouse Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.62 pg/ml - 1000 pg/ml | < 6.7 pg/ml | 525 | 96 tests | RUO | |
Abbexa | TREM1 | abx491224 | Pig Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) CLIA Kit | Pig | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 31.25 pg/ml - 2000 pg/ml | < 12.4 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | TREM1 | abx155018 | Pig Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) ELISA Kit | Pig | Serum,Plasma,Other biological fluids | Sandwich | 31.25 pg/ml - 2000 pg/ml | < 12.4 pg/ml | 712.5 | 96 tests | RUO | |
FineTest | TREM1 | ER1403 | Rat TREM-1(Triggering Receptor Expresses on Myeloid Cells-1) ELISA Kit | rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 7.813-500pg/ml | 96T | D4ABU7 | RUO | ||
Abbexa | TREM1 | abx256070 | Rat Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 7.81 pg/ml - 500 pg/ml | 4.69 pg/ml | 531.25 | 96 tests | D4ABU7 | RUO |
Abbexa | TREM1 | abx197846 | Rat Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) CLIA Kit | Rat | Serum, plasma and other biological fluids. | 3.13 pg/ml - 200 pg/ml | 1.88 pg/ml | 618.75 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TREM1 | abx104823 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody | Cow | Polyclonal | Rabbit | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | RUO | ||
FineTest | TREM1 | FNab10738 | anti- TREM1 antibody | human | polyclonal | Rabbit | triggering receptor expressed on myeloid cells 1 | IgG | Unconjugated | ELISA, WB, IHC | 100µg | Q9NP99 | RUO | |
FineTest | TREM1 | FNab08960 | anti- TREM1 antibody | human | polyclonal | Rabbit | triggering receptor expressed on myeloid cells 1 | IgG | Unconjugated | ELISA, WB, IF, FC | 100µg | Q9NP99 | RUO | |
FineTest | TREM1 | FNab09969 | anti- TREM1 antibody | human | polyclonal | Rabbit | triggering receptor expressed on myeloid cells 1 | IgG | Unconjugated | ELISA, WB | 100µg | Q9NP99 | RUO | |
Abbexa | TREM1 | abx000673 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody | Human | Polyclonal | Rabbit | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Unconjugated | WB | 175 | 20 µl | Q9NP99 | RUO | |
Abbexa | TREM1 | abx104522 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody | Human | Polyclonal | Rabbit | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Unconjugated | WB, IHC, IF/ICC | 250 | 100 µl | Q9NP99 | RUO | |
Abbexa | TREM1 | abx174929 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody | Human | Monoclonal | Mouse | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Unconjugated | WB, IHC, IF/ICC | 712.5 | 1 ml | RUO | ||
Abbexa | TREM1 | abx321541 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody | Human | Polyclonal | Rabbit | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Unconjugated | ELISA, WB | 237.5 | 50 µl | Q9NP99 | RUO | |
Abbexa | TREM1 | abx030591 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody | Human | Polyclonal | Rabbit | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Unconjugated | ELISA, WB | 250 | 80 µl | Q9NP99 | RUO | |
Abbexa | TREM1 | abx116261 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody | Human | Polyclonal | Rabbit | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q9NP99 | RUO | |
Abbexa | TREM1 | abx270616 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody (APC) | Human | Polyclonal | Rabbit | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | APC | FCM | 800 | 200 tests | RUO | ||
Abbexa | TREM1 | abx270848 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody (PE) | Human | Polyclonal | Rabbit | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | PE | FCM | 687.5 | 200 tests | RUO | ||
Abbexa | TREM1 | abx270086 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody | Human | Polyclonal | Rabbit | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Unconjugated | FCM | 275 | 50 tests | RUO | ||
Abbexa | TREM1 | abx323793 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody | Human | Polyclonal | Rabbit | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q9NP99 | RUO | |
Abbexa | TREM1 | abx270384 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody (FITC) | Human | Polyclonal | Rabbit | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | FITC | FCM | 575 | 200 tests | RUO | ||
Abbexa | TREM1 | abx240192 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody | Human | Polyclonal | Rabbit | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | Q9NP99 | RUO | |
Abbexa | TREM1 | abx238960 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody | Human | Polyclonal | Rabbit | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Unconjugated | ELISA, WB, IF/ICC, FCM | 350 | 100 µg | Q9NP99 | RUO | |
Abbexa | TREM1 | abx219124 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody | Human | Polyclonal | Rabbit | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Unconjugated | ELISA, WB | 350 | 100 µg | Q9NP99 | RUO | |
Abbexa | TREM1 | abx414360 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody | Mouse | Monoclonal | Rat | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Unconjugated | WB, IHC, IF/ICC, FCM | 462.5 | 250 µg | Q9JKE2 | RUO | |
Abbexa | TREM1 | abx414364 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody (PE) | Mouse | Monoclonal | Rat | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | PE | FCM | 487.5 | 100 tests | Q9JKE2 | RUO | |
Abbexa | TREM1 | abx414361 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody | Mouse | Monoclonal | Rat | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Unconjugated | WB, IHC, IF/ICC, FCM | 737.5 | 500 µg | Q9JKE2 | RUO | |
Abbexa | TREM1 | abx104521 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody | Mouse | Polyclonal | Rabbit | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Unconjugated | WB, IHC, IF/ICC | 212.5 | 100 µl | Q9JKE2 | RUO | |
Abbexa | TREM1 | abx414363 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody | Mouse | Monoclonal | Rat | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Unconjugated | WB, IHC, IF/ICC, FCM | 337.5 | 100 µg | Q9JKE2 | RUO | |
Abbexa | TREM1 | abx104524 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody | Pig | Polyclonal | Rabbit | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | Q6TYI6 | RUO | |
Abbexa | TREM1 | abx174930 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody | Pig | Monoclonal | Mouse | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Unconjugated | WB, IHC, IF/ICC | 850 | 1 ml | RUO | ||
Abbexa | TREM1 | abx274621 | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Antibody (Biotin) | Pig | Polyclonal | Rabbit | Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) | Biotin | WB, IHC, IF/ICC | 387.5 | 200 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TREM1 | abx069479 | Human Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | Q9NP99 | RUO |
Abbexa | TREM1 | abx262303 | Triggering Receptor Expressed on Myeloid Cells 1 Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | Q9NP99 | RUO | ||
Abbexa | TREM1 | abx166282 | Cow Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Protein | Cow | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 425 | 50 µg | Q6QUN5 | RUO |
Abbexa | TREM1 | abx069482 | Pig Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Protein | Pig | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 425 | 50 µg | Q6TYI6 | RUO |
Abbexa | TREM1 | abx069480 | Mouse Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q9JKE2 | RUO |
Abbexa | TREM1 | abx655339 | Rat Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 1800 | 1 mg | RUO |
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