Family main features
SLAMF7 (SLAM Family Member 7), also known as CS1 (CD2 subset 1) or CRACC (CD319), is a cell surface glycoprotein belonging to the Signaling Lymphocyte Activation Molecule (SLAM) family within the immunoglobulin superfamily. SLAMF7 is primarily expressed on the surface of immune cells, especially on natural killer (NK) cells, plasma cells, and certain T-cell subsets, as well as dendritic cells and monocytes. This receptor plays a key role in immune cell activation, adhesion, and signal transduction, significantly influencing immune responses.
SLAMF7 is particularly relevant in the context of immune surveillance and tumor cell recognition, as it acts as a co-stimulatory molecule for NK cells, enhancing their cytotoxic function against abnormal cells. In the tumor microenvironment, SLAMF7 can either promote anti-tumor immunity or, in some cases, contribute to immune evasion mechanisms that facilitate cancer cell survival. Its expression in multiple myeloma, where it is typically highly expressed, has made it a target for immunotherapy. The development of monoclonal antibodies against SLAMF7, like elotuzumab, has underscored its significance in cancer therapy.
SLAMF7 is a type I transmembrane protein with a well-defined structure that facilitates its function in immune cell interactions and signaling:
Extracellular Domain:
Transmembrane Domain:
Intracellular (Cytoplasmic) Domain:
SLAMF7 is part of the SLAM family of receptors, which includes other related proteins like SLAMF1, SLAMF2, and SLAMF3. These proteins are characterized by similar structural features, including the presence of immunoglobulin-like domains and ITSM motifs in their cytoplasmic tails. Although no direct subtypes of SLAMF7 exist, the entire SLAM family shares a conserved role in immune regulation through homophilic interactions and engagement with adaptor proteins like SAP. The SLAM receptors are widely studied for their involvement in both innate and adaptive immune responses, with SLAMF7 standing out for its significant role in modulating NK cell function.
SLAMF7 is involved in various immune cell processes, particularly in enhancing immune cell-mediated cytotoxicity and cytokine production:
Regulation of NK Cell Activity:
Role in Plasma Cells and Myeloma:
Signal Transduction and Immune Modulation:
Modulation of Immune Surveillance in Cancer:
SLAMF7’s involvement in immune cell regulation has made it a focus of clinical research, particularly in cancer immunotherapy:
Therapeutic Target in Multiple Myeloma:
Potential Implications in Autoimmune Disorders:
Role in Infectious Disease:
SLAMF7, a type I transmembrane glycoprotein in the SLAM family, is crucial for regulating immune cell activation, particularly in NK cells and plasma cells. Structurally, SLAMF7 features extracellular immunoglobulin-like domains that facilitate interactions with other immune cells, a transmembrane domain for membrane localization, and an intracellular ITSM motif critical for signal transduction. Through its signaling capabilities, SLAMF7 enhances NK cell cytotoxicity and plays a role in immune surveillance against tumors and infected cells.
SLAMF7’s overexpression in multiple myeloma has spurred the development of targeted therapies, with elotuzumab marking a breakthrough in immunotherapy by exploiting SLAMF7 to direct NK cells against malignant cells. While SLAMF7’s primary significance lies in cancer immunotherapy, it has broader implications for immune modulation, with potential roles in infectious diseases and autoimmune conditions. Overall, SLAMF7 is an important immune regulatory molecule with a promising therapeutic potential due to its unique role in immune cell signaling and tumor recognition.
SLAM family member 7 (SLAMF7)
CD2 subset 1,19A,CS1,CD319,CRACC,CD2-like receptor-activating cytotoxic cells,Membrane protein FOAP-12
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con SLAMF7 - SLAM family member 7
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Esta página contiene 19 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | SLAMF7 | EH12321 | Human SLAMF7 (SLAM family member 7)ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 78.125-5000pg/ml | 96T | Q9NQ25 | RUO | ||
Abbexa | SLAMF7 | abx153101 | Human Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | SLAMF7 | abx495855 | Human Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.055 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | SLAMF7 | abx546080 | Mouse SLAM family member 7 (SLAMF7) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8BHK6 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | SLAMF7 | FNab07903 | anti- SLAMF7 antibody | human | polyclonal | Rabbit | SLAM family member 7 | IgG | Unconjugated | ELISA, WB | 100µg | Q9NQ25 | RUO | |
Abbexa | SLAMF7 | abx115587 | Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Antibody | Human | Polyclonal | Rabbit | Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q9NQ25 | RUO | |
Abbexa | SLAMF7 | abx129220 | Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Antibody | Human | Polyclonal | Rabbit | Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | Q9NQ25 | RUO | |
Abbexa | SLAMF7 | abx349954 | SLAM family member 7 (SLAMF7) Antibody | Human | Monoclonal | Mouse | SLAM family member 7 (SLAMF7) | Unconjugated | ELISA, IHC, FCM | 287.5 | 50 µl | Q9NQ25 | RUO | |
Abbexa | SLAMF7 | abx237903 | Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Antibody | Human | Polyclonal | Rabbit | Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) | Unconjugated | ELISA, WB | 350 | 100 µg | Q9NQ25 | RUO | |
Abbexa | SLAMF7 | abx174554 | Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Antibody | Human | Monoclonal | Mouse | Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | SLAMF7 | abx122207 | Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Antibody | Human | Polyclonal | Rabbit | Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | SLAMF7 | abx274656 | Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Antibody (Biotin) | Human | Polyclonal | Rabbit | Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) | Biotin | WB, IHC, IF/ICC | 362.5 | 200 µl | Q9NQ25 | RUO | |
Abbexa | SLAMF7 | abx322233 | Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Antibody | Human | Polyclonal | Rabbit | Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) | Unconjugated | ELISA, WB, IHC | 237.5 | 50 µl | Q9NQ25 | RUO | |
Abbexa | SLAMF7 | abx004430 | Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Antibody | Human | Polyclonal | Rabbit | Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) | Unconjugated | WB | 175 | 20 µl | Q9NQ25 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | SLAMF7 | P6134 | Recombinant Mouse SLAMF7 | Mouse | Recombinant | E.Coli | Western Blot,ELISA | 50μg | Q8BHK6 | RUO | ||
Abbexa | SLAMF7 | abx167045 | Human Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO | |
Abbexa | SLAMF7 | abx690087 | Mouse Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Protein | Mouse | Recombinant | Human | SDS-PAGE | 212.5 | 10 µg | RUO | ||
Abbexa | SLAMF7 | abx680457 | Human Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Protein | Human | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 2 µg | RUO | |
Abbexa | SLAMF7 | abx692144 | Mouse Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | RUO |
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