Family main features
CLEC9A, also known as C-type lectin domain family 9 member A or DNGR-1 (Dendritic Cell Natural Killer Lectin Group Receptor 1), is an immune receptor primarily expressed on a subset of dendritic cells (DCs) and certain populations of macrophages. CLEC9A is part of the C-type lectin receptor (CLR) family, which is known for its role in recognizing carbohydrate structures on pathogens, triggering immune responses, and presenting antigens to T cells. However, CLEC9A is unique within this family for its specialized function in detecting necrotic cells and facilitating the cross-presentation of antigens from dead cells. This capability enables CLEC9A to bridge innate and adaptive immunity, playing a significant role in immune responses to infections, cancer, and tissue injury.
The receptor's ability to recognize damaged cells, rather than simply pathogens, underscores its importance in contexts such as infection, cancer immunology, and autoimmunity. CLEC9A has therefore gained interest for its potential applications in vaccine development and immunotherapy. Its expression is mainly restricted to CD8+ DCs and their human equivalent, BDCA3+ DCs, which are specialized for cross-presentation, making CLEC9A a critical component in inducing CD8+ T cell responses.
CLEC9A’s structure is integral to its ability to recognize ligands associated with necrotic cells and to initiate intracellular signaling:
Extracellular C-type Lectin-like Domain (CTLD):
Stalk Region:
Transmembrane Domain:
Cytoplasmic Tail with Immunoreceptor Tyrosine-based Activation Motif (ITAM)-like Domain:
CLEC9A is classified within the C-type lectin receptor family, specifically within a subgroup of CLRs that recognize cellular damage and aid in antigen presentation. While CLEC9A does not have major subtypes, it is closely related to other CLRs that interact with damaged cells or necrotic tissue, such as CLEC7A (Dectin-1) and CLEC4A (Dendritic Cell Immunoreceptor, DCIR), which also play roles in sensing cell damage or microbial components. CLEC9A’s expression on specialized dendritic cells (CD8+ DCs and BDCA3+ DCs) gives it a unique role in antigen cross-presentation, setting it apart from other CLRs with broader distribution patterns.
CLEC9A has several key functions, primarily in linking the detection of necrotic cells with the induction of adaptive immune responses:
Detection of Necrotic Cells:
Cross-Presentation of Antigens:
Promotion of Cytokine Production and Immune Activation:
Role in Cancer Immunity:
Cancer and Immunotherapy:
Autoimmunity and Inflammatory Diseases:
Infectious Diseases:
CLEC9A, or DNGR-1, is a C-type lectin receptor that plays a specialized role in detecting necrotic cells and facilitating antigen cross-presentation on dendritic cells. Its structure, featuring a C-type lectin-like domain adapted for binding actin and other necrotic cell markers, and an ITAM-like cytoplasmic tail for initiating immune signaling, makes CLEC9A highly effective in bridging innate and adaptive immunity. CLEC9A’s selective expression on CD8+ DCs (in mice) and BDCA3+ DCs (in humans) positions it as a key receptor in presenting antigens from damaged cells to CD8+ T cells, thus playing a central role in anti-tumor immunity and responses to intracellular pathogens.
Clinically, CLEC9A is a promising target in cancer immunotherapy and vaccine development, as its activation enhances the immune response to tumor antigens and may improve vaccine efficacy. Its role in inflammation also suggests potential implications in autoimmunity, where excessive responses to tissue damage could exacerbate disease. CLEC9A remains a focus of research in immunology and therapeutic development due to its unique role in sensing necrosis and presenting antigens to drive effective CD8+ T cell responses.
C-type lectin domain containing 9A (CLEC9A)
CD370,DNGR1,DNGR-1
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits) relacionados con CLEC9A - C-type lectin domain containing 9A
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 12 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
Contacta con nosotros en info@markelab.com, si necesitas mas informacion o alguna aclaracion. Te garantizamos respuesta en menos de 24 h.
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CLEC9A | abx386569 | Human C-Type Lectin Domain Family 9 Member A (CLEC9A) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.313 ng/ml - 20 ng/ml | < 0.188 ng/ml | 687.5 | 96 tests | Q6UXN8 | RUO |
Abbexa | CLEC9A | abx507151 | Mouse C-type lectin domain family 9 member A (CLEC9A) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8BRU4 | RUO | ||
Abbexa | CLEC9A | abx507152 | Rat C-Type Lectin Domain Family 9 Member A (CLEC9A) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | D4AD02 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | CLEC9A | FNab01758 | anti- CLEC9A antibody | human | polyclonal | Rabbit | C-type lectin domain family 9, member A | IgG | Unconjugated | ELISA, IHC | 100µg | Q6UXN8 | RUO | |
Abbexa | CLEC9A | abx140549 | C-Type Lectin Domain Family 9 Member A (CLEC9A) Antibody | Human | Monoclonal | Mouse | C-Type Lectin Domain Family 9 Member A (CLEC9A) | Unconjugated | IF/ICC, FCM | 337.5 | 0.1 mg | Q6UXN8 | RUO | |
Abbexa | CLEC9A | abx347139 | C-Type Lectin Domain Family 9 Member A (CLEC9A) Antibody (APC) | Human | Monoclonal | Mouse | C-Type Lectin Domain Family 9 Member A (CLEC9A) | APC | FCM | 400 | 100 tests | Q6UXN8 | RUO | |
Abbexa | CLEC9A | abx313455 | C-Type Lectin Domain Family 9 Member A (CLEC9A) Antibody (FITC) | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 9 Member A (CLEC9A) | FITC | 162.5 | 20 µg | Q6UXN8 | RUO | ||
Abbexa | CLEC9A | abx029711 | C-Type Lectin Domain Family 9 Member A (CLEC9A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 9 Member A (CLEC9A) | Unconjugated | ELISA, WB | 281.25 | 80 µl | Q6UXN8 | RUO | |
Abbexa | CLEC9A | abx318715 | C-Type Lectin Domain Family 9 Member A (CLEC9A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 9 Member A (CLEC9A) | Unconjugated | ELISA, IHC | 162.5 | 20 µg | Q6UXN8 | RUO | |
Abbexa | CLEC9A | abx313454 | C-Type Lectin Domain Family 9 Member A (CLEC9A) Antibody (HRP) | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 9 Member A (CLEC9A) | HRP | ELISA | 162.5 | 20 µg | Q6UXN8 | RUO | |
Abbexa | CLEC9A | abx313456 | C-Type Lectin Domain Family 9 Member A (CLEC9A) Antibody (Biotin) | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 9 Member A (CLEC9A) | Biotin | ELISA | 162.5 | 20 µg | Q6UXN8 | RUO | |
Abbexa | CLEC9A | abx231758 | C-Type Lectin Domain Family 9 Member A (CLEC9A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 9 Member A (CLEC9A) | Unconjugated | ELISA, IHC | 350 | 100 µg | Q6UXN8 | RUO |
Te recomendamos que si no encuentras lo que buscas, utilices el buscador, refinando la búsqueda según tu criterio y usando Alias, o bien contacta con nosotros.