Family main features
ADP-ribosyltransferase 1 (ART1) is an enzyme that belongs to the ART superfamily of proteins, which catalyze the transfer of ADP-ribose from NAD+ (nicotinamide adenine dinucleotide) to target proteins, a process known as mono-ADP-ribosylation. This post-translational modification alters the function of target proteins, influencing various cellular processes, including signal transduction, immune responses, cell differentiation, and apoptosis. ART1 is primarily expressed in immune cells and skeletal muscle tissues and has been associated with immune modulation, inflammatory responses, and cell adhesion. As ART1 modifies proteins by adding an ADP-ribose moiety, it has significant roles in regulating interactions between cells and in modulating the immune response, making it an area of interest in immunology and cancer research.
ART1 is a type I membrane-bound protein and part of the ecto-ADP-ribosyltransferase family, which is characterized by a conserved structure necessary for its enzymatic activity. ART1 consists of three primary domains:
Signal Peptide:
Catalytic Domain:
Glycosylphosphatidylinositol (GPI) Anchor:
ART1 belongs to the ART superfamily, which is further divided based on structure, cellular localization, and function. ART1 is classified as a GPI-anchored ecto-ADP-ribosyltransferase. Other members in this family include ART2, ART3, and ART4, which have similar functions but differ in tissue distribution, substrate specificity, and cellular localization. Among these, ART2 also plays an important role in immune modulation, particularly in T cells.
ART1 functions by transferring ADP-ribose from NAD+ to specific arginine residues on target proteins, a modification that impacts protein activity, localization, and interactions. The biological significance of ART1 stems from its ability to regulate immune functions, cell adhesion, and inflammation:
Modulation of Immune Response:
Cell Adhesion and Migration:
Inflammation and Tissue Repair:
Signal Transduction:
Autoimmune Disorders:
Cancer:
Chronic Inflammatory Diseases:
Muscle Disorders:
ART1, or ADP-ribosyltransferase 1, is an enzyme with critical functions in regulating immune responses, inflammation, and cell adhesion. It operates through the transfer of ADP-ribose to surface proteins on immune and other cell types, modifying protein functions and thereby impacting cellular processes essential for immune regulation, inflammation control, and cell communication. Structurally, ART1 is characterized by a signal peptide, a catalytic domain with a conserved ADP-ribosylation site, and a GPI anchor that localizes it to the cell surface, facilitating its interactions with extracellular substrates.
The enzyme’s function is significant in modulating immune responses, controlling inflammation, and regulating cell adhesion, which can affect wound healing, tissue repair, and immune surveillance. Clinically, ART1 dysregulation is associated with autoimmune diseases, chronic inflammatory conditions, and certain cancers, where its role in immune modulation and cell adhesion is often pathologically altered. Because of its involvement in these critical processes, ART1 presents a potential target for therapeutic interventions in various immune-mediated and inflammatory diseases, as well as in oncology.
ADP-ribosyltransferase 1 (ART1)
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1,RT6,ART2,ARTC1,CD296,ADP-ribosyltransferase C2 and C3 toxin-like 1,Mono(ADP-ribosyl)transferase 1
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con ART1 - ADP-ribosyltransferase 1
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Esta página contiene 11 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | ART1 | EH13952 | Human ART1(GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | P52961 | RUO | ||
Abbexa | ART1 | abx384557 | Human ADP Ribosyltransferase 1 (ART1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.1 ng/ml | 687.5 | 96 tests | P52961 | RUO |
Abbexa | ART1 | abx495153 | Mouse ADP Ribosyltransferase 1 (ART1) CLIA Kit | Mouse | Tissue homogenates and other biological fluids. | Sandwich | 0.781 ng/ml - 50 ng/ml | < 0.32 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | ART1 | abx153676 | Mouse ADP Ribosyltransferase 1 (ART1) ELISA Kit | Mouse | Tissue homogenates,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | < 0.32 ng/ml | 687.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ART1 | abx341275 | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (ART1) Antibody (HRP) | Human | Polyclonal | Rabbit | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (ART1) | HRP | ELISA | 250 | 50 µl | P52961 | RUO | |
Abbexa | ART1 | abx341274 | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (ART1) Antibody | Human | Polyclonal | Rabbit | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (ART1) | Unconjugated | ELISA, IHC | 250 | 50 µl | P52961 | RUO | |
Abbexa | ART1 | abx341276 | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (ART1) Antibody (FITC) | Human | Polyclonal | Rabbit | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (ART1) | FITC | 250 | 50 µl | P52961 | RUO | ||
Abbexa | ART1 | abx341277 | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (ART1) Antibody (Biotin) | Human | Polyclonal | Rabbit | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (ART1) | Biotin | ELISA | 250 | 50 µl | P52961 | RUO | |
Abbexa | ART1 | abx323350 | ADP Ribosyltransferase 1 (ART1) Antibody | Human | Polyclonal | Rabbit | ADP Ribosyltransferase 1 (ART1) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P52961 | RUO | |
Abbexa | ART1 | abx136013 | ADP Ribosyltransferase 1 (ART1) Antibody | Human | Polyclonal | Rabbit | ADP Ribosyltransferase 1 (ART1) | Unconjugated | WB, IHC, IF/ICC | 175 | 20 µl | P52961 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ART1 | abx652403 | Mouse ADP Ribosyltransferase 1 (ART1) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | RUO |
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