Family main features
CD300LB, also known as CD300 molecule-like family member B, is a member of the CD300 family of receptors, which play significant roles in regulating immune responses. This family includes a range of receptors that can either activate or inhibit immune cell functions, contributing to the fine-tuning of immune responses. CD300LB is encoded by the gene located on human chromosome 17q25, which is a region rich in genes involved in immune regulation.
CD300LB is expressed on various immune cells, particularly myeloid cells, such as monocytes, macrophages, and dendritic cells. It functions primarily as an activating receptor, participating in the modulation of inflammatory responses and pathogen defense mechanisms.
CD300LB is a type I transmembrane glycoprotein characterized by the following structural features:
CD300LB belongs to the CD300 family of receptors, which are classified based on the presence of ITIMs (inhibitory motifs) or ITAMs (activating motifs) in their cytoplasmic tails:
The CD300 family members share structural similarities but have distinct functions, allowing them to regulate immune responses through both activation and inhibition.
CD300LB plays several critical roles in the regulation of immune responses:
CD300LB's role in immune regulation has implications for various clinical conditions:
CD300LB is an important activating receptor in the CD300 family, predominantly expressed on myeloid cells. Structurally, it features an extracellular Ig-like domain, a transmembrane region, and a cytoplasmic tail with an ITAM that mediates activating signals. CD300LB plays significant roles in activating immune responses, enhancing phagocytosis, and promoting cytokine production. Its involvement in various clinical conditions, including autoimmune diseases, infections, inflammatory conditions, and cancer, underscores its importance in immune regulation. Understanding the precise mechanisms of CD300LB's function and its interactions with other immune molecules is essential for developing targeted therapies aimed at modulating immune responses in diverse diseases.
CD300 molecule like family member b (CD300LB)
CD300B,CLM7,CMRF35A2,IREM3,LMIR5,TREM5, Immune receptor expressed on myeloid cells 3,Leukocyte mono-Ig-like receptor 5,Triggering receptor expressed on myeloid cells 5,CD300 antigen-like family member B,CMRF35-like molecule 7
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits) relacionados con CD300LB molecule like family member b
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 6 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | CD300LB | EH1453 | Human CD300LB(CMRF35-like molecule 7) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 78.125-5000pg/ml | 96T | A8K4G0 | RUO | ||
Abbexa | CD300LB | abx250732 | Human CMRF35-Like Molecule 7 / IREM-3 (CD300LB) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 687.5 | 96 tests | A8K4G0 | RUO | |
FineTest | CD300LB | EM0567 | Mouse CD300lb(CMRF35-like molecule 7) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 78.125-5000pg/ml | 96T | Q3U497 | RUO | ||
Abbexa | CD300LB | abx254918 | Mouse CMRF35-Like Molecule 7 / IREM-3 (CD300LB) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 687.5 | 96 tests | Q3U497 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CD300LB | abx032437 | CMRF35-Like Molecule 7 / IREM-3 (CD300LB) Antibody | Human | Polyclonal | Rabbit | CMRF35-Like Molecule 7 / IREM-3 (CD300LB) | Unconjugated | ELISA, WB | 250 | 80 µl | A8K4G0 | RUO | |
Abbexa | CD300LB | abx303344 | CMRF35-Like Molecule 7 / IREM-3 (CD300LB) Antibody | Human | Polyclonal | Rabbit | CMRF35-Like Molecule 7 / IREM-3 (CD300LB) | Unconjugated | ELISA | 162.5 | 20 µg | A8K4G0 | RUO |
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