Family main features
CD300C, also known as immune receptor expressed by myeloid cells 2 (IREM-2), is a member of the CD300 family of immunoreceptors. The CD300 family, also known as the LMIR (leukocyte mono-immunoglobulin-like receptor) family, consists of several proteins that are predominantly expressed on the surface of myeloid and some lymphoid cells. These receptors are involved in the regulation of various immune responses, both activating and inhibitory, contributing to immune homeostasis and protection against pathogens.
CD300C is encoded by the CD300C gene located on chromosome 17q25.1 in humans. This receptor is structurally similar to other members of the CD300 family, particularly CD300A, but it has distinct functional properties that are crucial for modulating immune cell activity.
CD300C is a type I transmembrane protein with the following structural features:
CD300C is part of the CD300 family, which includes both activating and inhibitory receptors. Members of this family are classified based on the presence of ITIMs or ITAMs in their cytoplasmic tails:
Other notable members of the CD300 family include CD300A, CD300B, CD300D, CD300E, CD300F, and CD300G. Each of these receptors plays a unique role in regulating immune cell functions.
CD300C is primarily involved in the activation of immune responses. Its functions and biological significance include:
CD300C is implicated in various clinical conditions, primarily due to its role in immune activation:
CD300C is a crucial activating receptor in the CD300 family, expressed predominantly on myeloid cells. Structurally, it features an extracellular Ig-like domain, a transmembrane region, and a cytoplasmic tail with an ITAM that mediates activating signals. CD300C plays significant roles in activating immune responses, regulating inflammatory processes, and influencing adaptive immunity. Its involvement in various clinical conditions, including autoimmune diseases, infections, allergies, and cancer, underscores its importance in immune regulation. Understanding the precise mechanisms of CD300C's function and its interactions with other immune molecules is essential for developing targeted therapies aimed at modulating immune responses in diverse diseases.
CD300c molecule (CD300C)
CMRF35,CMRF35A,CMRF35A1,IGSF16,Immunoglobulin superfamily member 16,CD300 antigen-like family member C,CLM-6,CMRF35-like molecule 6
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con CD300C molecule
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 6 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CD300C | abx507333 | Human CMRF35-like molecule 6 (CD300C) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q08708 | RUO | ||
Abbexa | CD300C | abx507334 | Mouse CMRF35-like molecule 6 (CD300C) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | A2A7V7 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CD300C | abx029106 | CMRF35-Like Molecule 6 (CD300C) Antibody | Human | Polyclonal | Rabbit | CMRF35-Like Molecule 6 (CD300C) | Unconjugated | ELISA, WB | 250 | 80 µl | Q08708 | RUO | |
Abbexa | CD300C | abx323352 | CMRF35-Like Molecule 6 (CD300C) Antibody | Human | Polyclonal | Rabbit | CMRF35-Like Molecule 6 (CD300C) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q08708 | RUO | |
Abbexa | CD300C | abx125634 | CMRF35-Like Molecule 6 (CD300C) Antibody | Human | Polyclonal | Rabbit | CMRF35-Like Molecule 6 (CD300C) | Unconjugated | WB | 175 | 20 µl | Q08708 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CD300C | abx680429 | Human CMRF35-like molecule 6 (CD300C) Protein | Human | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 1 µg | RUO |
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