Family main features
AKR1D1, or Aldo-keto reductase family 1 member D1, is an enzyme that plays a crucial role in steroid metabolism. Specifically, it is involved in the conversion of bile acids from cholesterol. Bile acids are essential for the digestion and absorption of fats in the intestine. AKR1D1 catalyzes the NADPH-dependent reduction of Δ4-3-oxo steroids, including cortisol, cortisone, and testosterone, to their respective 3β-hydroxy steroids. This enzyme also converts 7α-hydroxycholesterol to 7α-hydroxy-4-cholesten-3-one, an important intermediate in bile acid synthesis. Mutations or deficiencies in AKR1D1 can lead to bile acid deficiency syndromes, which are characterized by impaired synthesis of bile acids, leading to liver and metabolic problems. Deficiencies in AKR1D1 can also result in accumulation of toxic intermediates, causing liver damage.
Aldo-keto reductase family 1 member D (AKR1D1) is an enzyme integral to the metabolism of steroids and bile acids. With a conserved (α/β)8-barrel structure and a catalytic tetrad, AKR1D1 functions to reduce Δ^4-3-oxosteroids, facilitating the proper metabolism and detoxification of these compounds. It plays critical roles in maintaining hormonal balance and bile acid homeostasis. Clinical implications of AKR1D1 include bile acid metabolism disorders, liver diseases, and potential roles in cancer progression. Understanding and targeting AKR1D1 can provide insights into therapeutic approaches for related metabolic and liver disorders.
Aldo-keto reductase family 1 member D1(AKR1D1)
AKR1D1,SRD5B1
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con AKR1D- Aldo-keto reductase family 1 member D
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 13 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
Contacta con nosotros en info@markelab.com, si necesitas mas informacion o alguna aclaracion. Te garantizamos respuesta en menos de 24 h.
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | AKR1D1 | abx385692 | Human 3-Oxo-5-Beta-Steroid 4-Dehydrogenase (AKR1D1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | P51857 | RUO |
Abbexa | AKR1D1 | abx501379 | Mouse 3-oxo-5-beta-steroid 4-dehydrogenase (AKR1D1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8VCX1 | RUO | ||
Abbexa | AKR1D1 | abx501381 | Rat 3-Oxo-5-Beta-Steroid 4-Dehydrogenase (AKR1D1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P31210 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | AKR1D1 | FNab00265 | anti- AKR1D1 antibody | human | polyclonal | Rabbit | aldo-keto reductase family 1, member D1(delta 4-3-ketosteroid-5-beta-reductase) | IgG | Unconjugated | ELISA, WB | 100µg | P51857 | RUO | |
Abbexa | AKR1D1 | abx037326 | 3-Oxo-5-Beta-Steroid 4-Dehydrogenase (AKR1D1) Antibody | Human | Polyclonal | Rabbit | 3-Oxo-5-Beta-Steroid 4-Dehydrogenase (AKR1D1) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | AKR1D1 | abx303028 | 3-Oxo-5-Beta-Steroid 4-Dehydrogenase (AKR1D1) Antibody | Human | Polyclonal | Rabbit | 3-Oxo-5-Beta-Steroid 4-Dehydrogenase (AKR1D1) | Unconjugated | ELISA, IHC | 162.5 | 20 µg | P51857 | RUO | |
Abbexa | AKR1D1 | abx028979 | 3-Oxo-5-Beta-Steroid 4-Dehydrogenase (AKR1D1) Antibody | Human | Polyclonal | Rabbit | 3-Oxo-5-Beta-Steroid 4-Dehydrogenase (AKR1D1) | Unconjugated | ELISA, WB | 250 | 80 µl | P51857 | RUO | |
Abbexa | AKR1D1 | abx230265 | 3-Oxo-5-Beta-Steroid 4-Dehydrogenase (AKR1D1) Antibody | Human | Polyclonal | Rabbit | 3-Oxo-5-Beta-Steroid 4-Dehydrogenase (AKR1D1) | Unconjugated | ELISA, WB | 350 | 100 µg | P51857 | RUO | |
Abbexa | AKR1D1 | abx242054 | 3-Oxo-5-Beta-Steroid 4-Dehydrogenase (AKR1D1) Antibody | Human | Polyclonal | Rabbit | 3-Oxo-5-Beta-Steroid 4-Dehydrogenase (AKR1D1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P51857 | RUO | |
Abbexa | AKR1D1 | abx241848 | 3-Oxo-5-Beta-Steroid 4-Dehydrogenase (AKR1D1) Antibody | Human | Polyclonal | Rabbit | 3-Oxo-5-Beta-Steroid 4-Dehydrogenase (AKR1D1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P51857 | RUO | |
Abbexa | AKR1D1 | abx123664 | 3-Oxo-5-Beta-Steroid 4-Dehydrogenase (AKR1D1) Antibody | Human | Polyclonal | Rabbit | 3-Oxo-5-Beta-Steroid 4-Dehydrogenase (AKR1D1) | Unconjugated | WB | 175 | 20 µl | P51857 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | AKR1D1 | P5337 | Recombinant Human AKR1D1 | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | P51857 | RUO | ||
Abbexa | AKR1D1 | abx073203 | Human 3-Oxo-5-Beta-Steroid 4-Dehydrogenase (AKR1D1) Protein | Human | Recombinant | E. coli | SDS-PAGE | 225 | 5 µg | P51857 | RUO |
Te recomendamos que si no encuentras lo que buscas, utilices el buscador, refinando la búsqueda según tu criterio y usando Alias, o bien contacta con nosotros.