Zinc Finger E-Box-Binding Homeobox 1 (ZEB1) Antibody
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Description
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described. This antibody is supplied as crude ascites.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Zinc Finger E-Box-Binding Homeobox 1 (ZEB1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/16000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 Kappa |
| Purification | Unpurified crude ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, FCM |
| Buffer | Ascites containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P37275 |
| Background | Antibody anti-ZEB1 |
| Status | RUO |
Descripción
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Human ZEB1 (Zinc finger E-box-binding homeobox 1) ELISA Kit
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ZEB1 antibody
Acts as a transcriptional repressor. Inhibits interleukin-2(IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition(EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box(5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. The calculated molecular weight of ZEB1 is 124 kDa, but the post phosphorylation of protein is about 190-210 kDa. This is a rabbit polyclonal antibody raised against part of the full length of ZEB1 of human.
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