Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
260€ (50 µg)
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935106861
info@markelab.com
name
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx455309
tested applications
ELISA, WB, IHC
Description
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody is a Rabbit polyclonal antibody for the detection of Human Von Hippel-Lindau Disease Tumor Suppressor (VHL).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Von Hippel-Lindau Disease Tumor Suppressor (VHL) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8 °C for up to 2 weeks. For long-term storage, aliquot and store at -80 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P40337 |
| Gene ID | 7428 |
| NCBI Accession | NP_000542.1 |
| Background | Antibody anti-VHL |
| Status | RUO |
Descripción
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Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor(HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
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