Vitamin D3 Receptor (VDR) Antibody
468€ (100 µl)
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name
Vitamin D3 Receptor (VDR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx117247
tested applications
ELISA, WB, IHC
Description
VDR Antibody is a Rabbit Polyclonal antibody against VDR. The vitamin D receptor (VDR), also known as the calcitriol receptor, and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factorsUpon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene productsIt is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effectsDownstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancerDefects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A)A disorder of vitamin D metabolism results in severe rickets, hypocalcemia and secondary hyperpaRathyroidismMost patients have total alopecia in addition to ricketsThis antibody is a rabbit polyclonal antibody to human VDR.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Vitamin D3 Receptor (VDR) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P11473 |
| Gene ID | 7421 |
| Alias | NR1I1,PPP1R163,Vitamin D3 receptor,1,25-dihydroxyvitamin D3 receptor,Nuclear receptor subfamily 1 group I member 1 |
| Background | Antibody anti-VDR |
| Status | RUO |
Descripción
Vitamin D receptor (VDR) is a nuclear receptor that mediates the effects of vitamin D, a crucial nutrient involved in calcium and phosphate homeostasis, bone health, immune function, and cellular growth VDR is activated upon binding to the active form of vitamin D, calcitriol, which allows it to regulate gene expression by binding to vitamin D response elements (VDREs) in target genes VDR is involved in regulating calcium absorption in the intestine, bone mineralization, and the modulation of immune responses, particularly in regulating inflammation and the function of T cells It also plays a role in the prevention of certain cancers, cardiovascular diseases, and autoimmune disorders Dysregulation of VDR activity has been linked to diseases such as osteoporosis, rickets, cardiovascular disease, and cancer In addition, VDR is a target for therapies aimed at managing conditions related to vitamin D deficiency, autoimmune diseases, and bone disorders
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