Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 phospho-Tyr1333 (FLT1 pY1333) Cell ELISA Kit
546€ (192 tests)
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Name
Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 phospho-Tyr1333 (FLT1 pY1333) Cell ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx596070
Tested Applications
ELISA
Description
Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 phospho-Tyr1333 (FLT1 pY1333) Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Immunogen Target | Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 phospho-Tyr1333 (FLT1 pY1333) |
| Reactivity | Human, Mouse, Rat |
| Detection Method | Fluorometric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 192 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P17948 |
| Gene ID | 2321 |
| OMIM | 165070 |
| Alias | FLT,FLT-1,VEGFR1,VEGFR-1,Vascular permeability factor receptor,Fms-like tyrosine kinase 1,Vascular endothelial growth factor receptor 1 |
| Background | Elisa Kits for: FLT1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Background
Fms related receptor tyrosine kinase 1 (FLT1) FLT1, also known as vascular endothelial growth factor receptor 1 (VEGFR1), is a transmembrane tyrosine kinase receptor that binds vascular endothelial growth factors (VEGFs) and placental growth factor (PlGF). FLT1 plays a crucial role in angiogenesis, vascular development, and inflammation by regulating endothelial cell proliferation, migration, and survival. Structurally, FLT1 consists of an extracellular ligand-binding domain with seven immunoglobulin-like loops, a transmembrane domain, and an intracellular kinase domain. FLT1 can function as a signaling receptor or a decoy receptor, depending on its membrane-bound or soluble isoforms, modulating VEGF availability and signaling intensity. It is highly expressed in endothelial cells and trophoblasts, contributing to processes such as placental development and vascular remodeling. Dysregulation of FLT1 is implicated in pathological conditions, including cancer, where it promotes tumor angiogenesis, and preeclampsia, where excessive FLT1 activity leads to impaired placental and vascular function. Its dual role as a regulator of VEGF signaling and a therapeutic target underscores its importance in both physiological and pathological angiogenesis.
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