Vav 3 Oncogene (VAV3) Antibody
286€ (100 µl)
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935106861
info@markelab.com
name
Vav 3 Oncogene (VAV3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx101252
tested applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Vav 3 Oncogene (VAV3).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Vav 3 Oncogene (VAV3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1-5 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | VAV-3 |
| Background | Antibody anti-VAV3 |
| Status | RUO |
Descripción
VAV3 is a member of the VAV family of guanine nucleotide exchange factors (GEFs) that regulate Rho family GTPases, such as Rac1, RhoA, and Cdc42, to mediate cytoskeletal reorganization, cell migration, and proliferation. VAV3 is expressed in multiple tissues, including the brain, endothelial cells, and immune cells, where it functions in signaling pathways downstream of receptor tyrosine kinases (RTKs), integrins, and immune receptors. It is involved in processes like angiogenesis, neuronal development, and immune cell activation. Dysregulation of VAV3 is associated with cancer, where it promotes tumor cell migration, metastasis, and survival through Rac1 activation and integrin signaling. VAV3 also plays a role in immune responses, including T-cell activation and macrophage function. Knockout studies demonstrate impaired angiogenesis, defective immune cell migration, and reduced tumor metastasis, highlighting its essential role in cytoskeletal regulation, cell signaling, and tumor progression.
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