Vasopressin V1b receptor (AVPR1B) Antibody (Biotin)
260€ (50 µl)
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Name
Vasopressin V1b receptor (AVPR1B) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx341327
Tested Applications
ELISA
Description
Vasopressin V1b receptor (AVPR1B) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin for the detection of Rat Avpr1b.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Vasopressin V1b receptor (AVPR1B) Immunogen: Recombinant Rat Vasopressin V1b receptor protein (224-284 AA) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Size 3 | 200 µl |
| Size 4 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P48974 |
| Alias | AVPR1B,Antidiuretic hormone receptor 1b,AVPR3,V3,V1bR,Vasopressin V3 receptor,VPR3,vasopressin V1b receptor,V3/V1b pituitary vasopressin receptor,V1bR,VPR7 |
| Background | Antibody anti-AVPR1B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AVPR1B is a G protein-coupled receptor that binds the hormone arginine vasopressin (AVP), a key regulator of water balance, blood pressure, and social behaviors. This receptor is primarily expressed in the anterior pituitary, where it plays an important role in the secretion of ACTH (adrenocorticotropic hormone) in response to stress. AVPR1B also plays a role in regulating behaviors associated with the stress response, including anxiety and social interactions. Upon activation, AVPR1B couples to Gq proteins, stimulating phospholipase C (PLC) and increasing intracellular calcium, leading to the release of ACTH from the pituitary gland. Dysregulation of AVPR1B is associated with stress-related disorders, such as anxiety and depression, and alterations in AVPR1B signaling have been implicated in diseases such as Cushing's syndrome and some forms of neuroendocrine tumors. Targeting AVPR1B with antagonists is being explored for the treatment of stress-related diseases and disorders linked to excessive ACTH secretion.
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