Vasopressin V1b Receptor (AVPR1B) Antibody
52€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Vasopressin V1b Receptor (AVPR1B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx119677
tested applications
WB
Description
AVPR1B Antibody is a Rabbit Polyclonal antibody against AVPR1B.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Vasopressin V1b Receptor (AVPR1B) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P47901 |
| Alias | AVPR1B,Antidiuretic hormone receptor 1b,AVPR3,V3,V1bR,Vasopressin V3 receptor,VPR3,vasopressin V1b receptor,V3/V1b pituitary vasopressin receptor,V1bR,VPR3 |
| Background | Antibody anti-AVPR1B |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
AVPR1B is a G protein-coupled receptor that binds the hormone arginine vasopressin (AVP), a key regulator of water balance, blood pressure, and social behaviors. This receptor is primarily expressed in the anterior pituitary, where it plays an important role in the secretion of ACTH (adrenocorticotropic hormone) in response to stress. AVPR1B also plays a role in regulating behaviors associated with the stress response, including anxiety and social interactions. Upon activation, AVPR1B couples to Gq proteins, stimulating phospholipase C (PLC) and increasing intracellular calcium, leading to the release of ACTH from the pituitary gland. Dysregulation of AVPR1B is associated with stress-related disorders, such as anxiety and depression, and alterations in AVPR1B signaling have been implicated in diseases such as Cushing's syndrome and some forms of neuroendocrine tumors. Targeting AVPR1B with antagonists is being explored for the treatment of stress-related diseases and disorders linked to excessive ACTH secretion.
Related Products
Human AVPR1B(Vasopressin V1b receptor) ELISA Kit
Ver Producto
Rat Avpr1b(Vasopressin V1b receptor) ELISA Kit
Ver Producto
Vasopressin V1b Receptor (AVPR1B) Antibody
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known.
Ver Producto