Rat Vascular Endothelial Growth Factor C (VEGFC) Protein (Active)
234€ (2 µg)
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name
Rat Vascular Endothelial Growth Factor C (VEGFC) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx263029
tested applications
SDS-PAGE
Description
Rat Vascular Endothelial Growth Factor C (VEGFC) Protein, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recombinant protein expressed in Sf9 Insect Cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Vascular Endothelial Growth Factor C (VEGFC) |
| Host | Insect |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Sequence Fragment: 101-221 AA. Tag: C-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE and RP-HPLC) |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Lyophilized Reconstitute in sterile 18 MΩ · cm water to a concentration of at least 100 µg/ml. This stock solution can be further diluted if required. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, containing 50 mg/ml BSA. |
| Availability | Shipped within 5-10 working days. |
| Storage | Stable at room temperature for up to 3 weeks. It is recommended to store this product desiccated at or below -18 °C. After reconstitution, store at 4 °C for short-term storage (up to 7 days) or below -18 °C for long-term storage. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O35757 |
| Alias | VRP,Flt4-L,LMPH1D,LMPHM4,Vascular endothelial growth factor-related protein |
| Background | Protein VEGFC |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
VEGFC is primarily responsible for lymphangiogenesis, the formation of lymphatic vessels, by binding to VEGFR-3 on lymphatic endothelial cells During embryonic development and tissue repair, VEGFC promotes the sprouting and maturation of lymphatic vessels VEGFC also activates VEGFR-2 in certain contexts, contributing to angiogenesis and vascular remodeling VEGFC plays a significant role in pathological processes, including cancer metastasis, where it enhances lymphatic vessel growth and facilitates tumor cell dissemination via the lymphatic system Overexpression of VEGFC is observed in various cancers such as breast cancer, melanoma, and prostate cancer, correlating with lymph node metastasis Targeting VEGFC signaling is a promising strategy to inhibit lymphangiogenesis and reduce cancer spread while maintaining tissue fluid balance and immune cell trafficking
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