Vascular Endothelial Growth Factor Receptor 3 / VEGFR3 (FLT4) Antibody
286€ (50 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Vascular Endothelial Growth Factor Receptor 3 / VEGFR3 (FLT4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx270193
Tested Applications
FCM
Description
Vascular Endothelial Growth Factor Receptor 3 / VEGFR3 (FLT4) Antibody is a Rabbit Polyclonal Antibody against Vascular Endothelial Growth Factor Receptor 3 / VEGFR3 (FLT4) for use in flow cytometry.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Vascular Endothelial Growth Factor Receptor 3 / VEGFR3 (FLT4) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 50 tests |
| Size 2 | 100 tests |
| Size 3 | 200 tests |
| Size 4 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | PCL,CHTD7,FLT-4,FLT41,LMPH1A,LMPHM1,VEGFR3,VEGFR-3,Tyrosine-protein kinase receptor FLT4,Fms-like tyrosine kinase 4,Vascular endothelial growth factor receptor 3 |
| Background | Antibody anti-FLT4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Fms related receptor tyrosine kinase 4 (FLT4) FLT4, also known as vascular endothelial growth factor receptor 3 (VEGFR3), is a receptor tyrosine kinase critical for the regulation of lymphangiogenesis, the formation of lymphatic vessels. Structurally, FLT4 comprises an extracellular domain with seven immunoglobulin-like loops, a single transmembrane domain, and an intracellular tyrosine kinase domain. FLT4 binds VEGF-C and VEGF-D ligands, leading to receptor dimerization and activation of downstream signaling pathways, including the MAPK and PI3K-AKT cascades. These pathways are essential for lymphatic endothelial cell proliferation, migration, and survival. FLT4 is predominantly expressed in lymphatic endothelial cells, where it plays a pivotal role in maintaining lymphatic vessel integrity and fluid homeostasis. Dysregulation of FLT4 has been linked to lymphedema, a condition characterized by lymphatic fluid accumulation, and its overexpression has been implicated in cancer progression, where it promotes tumor lymphangiogenesis and metastasis. FLT4 is a promising therapeutic target for modulating lymphatic function in both pathological and developmental contexts.
Productos relacionados
Vascular Endothelial Growth Factor Receptor 3 (FLT4) Antibody
This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to …
Ver producto
Vascular Endothelial Growth Factor Receptor 3 / VEGFR3 (FLT4) Antibody
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult l…
Ver producto
Human Vascular Endothelial Growth Factor Receptor 3 / VEGFR3 (FLT4) ELISA Kit
This product is currently under production. The lead time for this product may be several months. Please contact us at…
Ver producto