Vascular Endothelial Growth Factor Receptor 3 (FLT4) Antibody

Este producto es parte de FLT4 -  fms related receptor tyrosine kinase 4
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637€ (100 µl)

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935106861
info@markelab.com
name
Vascular Endothelial Growth Factor Receptor 3 (FLT4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx112565
tested applications
ELISA, WB

Description

Fms-Related Tyrosine Kinase 4 Antibody is a Rabbit Polyclonal antibody against Fms-Related Tyrosine Kinase 4.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetVascular Endothelial Growth Factor Receptor 3 (FLT4)
HostRabbit
ReactivityHuman
Recommended DilutionOptimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationAntigen Affinity Chromatography.
Size 1100 µl
FormLiquid
Tested ApplicationsELISA, WB
BufferPBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP35916
Gene ID2324
NCBI AccessionNP_002011.2, NM_002020.4, NP_891555.2, NM_182925.4
OMIM136352
AliasPCL,CHTD7,FLT-4,FLT41,LMPH1A,LMPHM1,VEGFR3,VEGFR-3,Tyrosine-protein kinase receptor FLT4,Fms-like tyrosine kinase 4,Vascular endothelial growth factor receptor 3
BackgroundAntibody anti-FLT4
StatusRUO

Descripción

Fms related receptor tyrosine kinase 4 (FLT4) FLT4, also known as vascular endothelial growth factor receptor 3 (VEGFR3), is a receptor tyrosine kinase critical for the regulation of lymphangiogenesis, the formation of lymphatic vessels. Structurally, FLT4 comprises an extracellular domain with seven immunoglobulin-like loops, a single transmembrane domain, and an intracellular tyrosine kinase domain. FLT4 binds VEGF-C and VEGF-D ligands, leading to receptor dimerization and activation of downstream signaling pathways, including the MAPK and PI3K-AKT cascades. These pathways are essential for lymphatic endothelial cell proliferation, migration, and survival. FLT4 is predominantly expressed in lymphatic endothelial cells, where it plays a pivotal role in maintaining lymphatic vessel integrity and fluid homeostasis. Dysregulation of FLT4 has been linked to lymphedema, a condition characterized by lymphatic fluid accumulation, and its overexpression has been implicated in cancer progression, where it promotes tumor lymphangiogenesis and metastasis. FLT4 is a promising therapeutic target for modulating lymphatic function in both pathological and developmental contexts.
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