Vascular Endothelial Growth Factor Receptor 2 / VEGFR2 (KDR) Antibody

Descripción

Vascular Endothelial Growth Factor Receptor 2 (VEGFR2/KDR) Antibody is a Rabbit Polyclonal antibody against Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2/KDR). Recombinant Human VEGFR2 ProteinTyrosine-Protein Kinase That Acts As A Cell-Surface Receptor For Vegfa, Vegfc And VegfdPlays An Essential Role In The Regulation Of Angiogenesis, Vascular Development, Vascular Permeability, And Embryonic HematopoiesisPromotes ProlifeRation, Survival, MigRation And Differentiation Of Endothelial CellsPromotes Reorganization Of The Actin CytoskeletonIsoforms Lacking A Transmembrane Domain, Such As Isoform 2 And Isoform 3, May Function As Decoy Receptors For Vegfa, Vegfc And/Or VegfdIsoform 2 Plays An Important Role As Negative Regulator Of Vegfa- And Vegfc-Mediated Lymphangiogenesis By Limiting The Amount Of Free Vegfa And/Or Vegfc And Preventing Their Binding To Flt4Modulates Flt1 And Flt4 Signaling By Forming HeterodimersBinding Of Vascular Growth Factors To Isoform 1 Leads To The Activation Of Several Signaling CascadesActivation Of Plcg1 Leads To The Production Of The Cellular Signaling Molecules Diacylglycerol And Inositol 1,4,5-Trisphosphate And The Activation Of Protein Kinase CMediates Activation Of Mapk1/Erk2, Mapk3/Erk1 And The Map Kinase Signaling Pathway, As Well As Of The Akt1 Signaling PathwayMediates Phosphorylation Of Pik3R1, The Regulatory Subunit Of Phosphatidylinositol 3-Kinase, Reorganization Of The Actin Cytoskeleton And Activation Of Ptk2/Fak1Required For Vegfa-Mediated Induction Of Nos2 And Nos3, Leading To The Production Of The Signaling Molecule Nitric Oxide (No) By Endothelial CellsPhosphorylates Plcg1Promotes Phosphorylation Of Fyn, Nck1, Nos3, Pik3R1, Ptk2/Fak1 And Src.