Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1) Antibody
234€ (50 µg)
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935106861
info@markelab.com
name
Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx375034
tested applications
ELISA, WB, IHC
Description
Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1) Antibody is a Mouse Monoclonal antibody against Human Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000 - 1/5000. Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified from mouse ascites by Protein G chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P17948-2 |
| Alias | FLT,FLT-1,VEGFR1,VEGFR-1,Vascular permeability factor receptor,Fms-like tyrosine kinase 1,Vascular endothelial growth factor receptor 1 |
| Background | Antibody anti-FLT1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Fms related receptor tyrosine kinase 1 (FLT1) FLT1, also known as vascular endothelial growth factor receptor 1 (VEGFR1), is a transmembrane tyrosine kinase receptor that binds vascular endothelial growth factors (VEGFs) and placental growth factor (PlGF). FLT1 plays a crucial role in angiogenesis, vascular development, and inflammation by regulating endothelial cell proliferation, migration, and survival. Structurally, FLT1 consists of an extracellular ligand-binding domain with seven immunoglobulin-like loops, a transmembrane domain, and an intracellular kinase domain. FLT1 can function as a signaling receptor or a decoy receptor, depending on its membrane-bound or soluble isoforms, modulating VEGF availability and signaling intensity. It is highly expressed in endothelial cells and trophoblasts, contributing to processes such as placental development and vascular remodeling. Dysregulation of FLT1 is implicated in pathological conditions, including cancer, where it promotes tumor angiogenesis, and preeclampsia, where excessive FLT1 activity leads to impaired placental and vascular function. Its dual role as a regulator of VEGF signaling and a therapeutic target underscores its importance in both physiological and pathological angiogenesis.
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