Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1) Antibody

Este producto es parte de FLT1 - fms related receptor tyrosine kinase 1
Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1) Antibody

Pida mas información

935106861

info@markelab.com

Precio

287.5€ (100 µl)

Antibody anti-FLT1

proveedor

Abbexa

reference

abx104456

Tested Applications

WB, IHC, IF/ICC

reactivity

Pig

status

RUO

clonality

Polyclonal

Descripción

Polyclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1).


Background

Fms related receptor tyrosine kinase 1 (FLT1) FLT1, also known as vascular endothelial growth factor receptor 1 (VEGFR1), is a transmembrane tyrosine kinase receptor that binds vascular endothelial growth factors (VEGFs) and placental growth factor (PlGF). FLT1 plays a crucial role in angiogenesis, vascular development, and inflammation by regulating endothelial cell proliferation, migration, and survival. Structurally, FLT1 consists of an extracellular ligand-binding domain with seven immunoglobulin-like loops, a transmembrane domain, and an intracellular kinase domain. FLT1 can function as a signaling receptor or a decoy receptor, depending on its membrane-bound or soluble isoforms, modulating VEGF availability and signaling intensity. It is highly expressed in endothelial cells and trophoblasts, contributing to processes such as placental development and vascular remodeling. Dysregulation of FLT1 is implicated in pathological conditions, including cancer, where it promotes tumor angiogenesis, and preeclampsia, where excessive FLT1 activity leads to impaired placental and vascular function. Its dual role as a regulator of VEGF signaling and a therapeutic target underscores its importance in both physiological and pathological angiogenesis.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Pig


immunogen target

Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1)


host

Rabbit


conjugation

Unconjugated


form

Liquid


tested applications

WB, IHC, IF/ICC


purification

Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.


buffer

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.


size 1

100 µl


size 2

200 µl


size 3

1 ml


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

FLT1


dry ice

No


availability

Shipped within 5-7 working days.


alias

FLT,FLT-1,VEGFR1,VEGFR-1,Vascular permeability factor receptor,Fms-like tyrosine kinase 1,Vascular endothelial growth factor receptor 1


note

This product is for research use only.


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