Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1) Antibody
Pida mas información
935106861
info@markelab.com
Precio
287.5€ (100 µl)
Antibody anti-FLT1
proveedor
Abbexareference
abx104456Tested Applications
WB, IHC, IF/ICCreactivity
Pigstatus
RUOclonality
PolyclonalDescripción
Polyclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1).
Background
Fms related receptor tyrosine kinase 1 (FLT1) FLT1, also known as vascular endothelial growth factor receptor 1 (VEGFR1), is a transmembrane tyrosine kinase receptor that binds vascular endothelial growth factors (VEGFs) and placental growth factor (PlGF). FLT1 plays a crucial role in angiogenesis, vascular development, and inflammation by regulating endothelial cell proliferation, migration, and survival. Structurally, FLT1 consists of an extracellular ligand-binding domain with seven immunoglobulin-like loops, a transmembrane domain, and an intracellular kinase domain. FLT1 can function as a signaling receptor or a decoy receptor, depending on its membrane-bound or soluble isoforms, modulating VEGF availability and signaling intensity. It is highly expressed in endothelial cells and trophoblasts, contributing to processes such as placental development and vascular remodeling. Dysregulation of FLT1 is implicated in pathological conditions, including cancer, where it promotes tumor angiogenesis, and preeclampsia, where excessive FLT1 activity leads to impaired placental and vascular function. Its dual role as a regulator of VEGF signaling and a therapeutic target underscores its importance in both physiological and pathological angiogenesis.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Pig
immunogen target
Vascular Endothelial Growth Factor Receptor 1 / VEGFR1 (FLT1)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
WB, IHC, IF/ICC
purification
Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
size 1
100 µl
size 2
200 µl
size 3
1 ml
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
FLT1
dry ice
No
availability
Shipped within 5-7 working days.
alias
FLT,FLT-1,VEGFR1,VEGFR-1,Vascular permeability factor receptor,Fms-like tyrosine kinase 1,Vascular endothelial growth factor receptor 1
note
This product is for research use only.
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