Vascular Endothelial Growth Factor B (VEGFB) Antibody

Descripción

VEGFB Antibody is a Rabbit Polyclonal antibody against VEGFB. Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular endothelial cellsVEGF and its close relatives VEGF-B, -C and -D form a subfamily within PDGF family of growth factors, which belongs to the cysteine knot class of cytokinesFive VEGF isoforms of 121, 145, 165, 189 and 206 amino acids (VEGF121–206) are geneRated as a result of alternative splicing from a single VEGF geneThe various VEGF forms bind to three tyrosine-kinase receptors, VEGFR-1, VEGFR-2 and VEGFR-3 which are expressed almost exclusively in endothelial cellsVEGFR-2 is the main angiogenic signal transducer for VEGF, while VEGFR-3 is specific for VEGF-C and -D and is necessary and sufficient for lymphangiogenic signalingHowever, upon proteolytic processing VEGF-C and -D gain the ability to also bind and activate VEGFR-2Guided by the binding properties of the ligands, the VEGFRs are able to form both homodimers and heterodimersReceptor dimerization is accompanied by activation of receptor kinase activity leading to receptor autophosphorylationPhosphorylated receptors recruit interacting proteins and induce downstream signalingRecently, tumor therapies based on neutralizing anti-VEGF antibodies and small molecule tyrosine kinase inhibitors targeting VEGFRs have been developedThese new stRategies for tumor treatment show the clinical relevance of inhibiting VEGF signal transduction pathways that are exaggeRated in pathological angiogenesisThis protein is involved in Cancer.