Vascular Endothelial Growth Factor B (VEGFB) Antibody

468€ (100 µl)
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name
Vascular Endothelial Growth Factor B (VEGFB) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx117220
tested applications
ELISA, WB, IHC
Description
VEGFB Antibody is a Rabbit Polyclonal antibody against VEGFB. Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular endothelial cellsVEGF and its close relatives VEGF-B, -C and -D form a subfamily within PDGF family of growth factors, which belongs to the cysteine knot class of cytokinesFive VEGF isoforms of 121, 145, 165, 189 and 206 amino acids (VEGF121–206) are geneRated as a result of alternative splicing from a single VEGF geneThe various VEGF forms bind to three tyrosine-kinase receptors, VEGFR-1, VEGFR-2 and VEGFR-3 which are expressed almost exclusively in endothelial cellsVEGFR-2 is the main angiogenic signal transducer for VEGF, while VEGFR-3 is specific for VEGF-C and -D and is necessary and sufficient for lymphangiogenic signalingHowever, upon proteolytic processing VEGF-C and -D gain the ability to also bind and activate VEGFR-2Guided by the binding properties of the ligands, the VEGFRs are able to form both homodimers and heterodimersReceptor dimerization is accompanied by activation of receptor kinase activity leading to receptor autophosphorylationPhosphorylated receptors recruit interacting proteins and induce downstream signalingRecently, tumor therapies based on neutralizing anti-VEGF antibodies and small molecule tyrosine kinase inhibitors targeting VEGFRs have been developedThese new stRategies for tumor treatment show the clinical relevance of inhibiting VEGF signal transduction pathways that are exaggeRated in pathological angiogenesisThis protein is involved in Cancer.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | Vascular Endothelial Growth Factor B (VEGFB) |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Purification | Purified by affinity chromatography. |
Size 1 | 100 µl |
Form | Liquid |
Tested Applications | ELISA, WB, IHC |
Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
Availability | Shipped within 5-10 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | P49765 |
Gene ID | 7423 |
Alias | VEGF-B,VEGF-related factor,VRF |
Background | Antibody anti-VEGFB |
Status | RUO |
Descripción
VEGFB is a member of the VEGF family that primarily regulates vascular growth and energy metabolism VEGFB binds to VEGFR-1 and Neuropilin-1 (NRP1) to control endothelial cell survival without significantly promoting angiogenesis VEGFB is involved in the transport of fatty acids across endothelial cells into tissues like cardiac muscle and skeletal muscle, where it supports energy homeostasis It is critical for maintaining the health of tissues with high metabolic demand, such as the heart and brain Dysregulation of VEGFB has been linked to metabolic disorders, cardiac hypertrophy, and atherosclerosis Elevated VEGFB expression can protect tissues under ischemic conditions by preserving vascular integrity and promoting fatty acid uptake, making it a potential target for therapeutic interventions in cardiovascular diseases and metabolic syndromes
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